Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats

Ischemic postconditioning (IPOC), or relief of ischemia in a stuttered manner, has emerged as an innovative treatment strategy to reduce programmed cell death, attenuate ischemic injuries, and improve neurological outcomes. However, the mechanisms involved have not been completely elucidated. Recent...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e46092
Hauptverfasser:	Gao, Li, Jiang, Teng, Guo, Jun, Liu, Yi, Cui, Guiyun, Gu, Lize, Su, Lingying, Zhang, Yingdong
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenine - analogs & derivatives Adenine - pharmacology Adenine - therapeutic use Animals Apoptosis Apoptosis Regulatory Proteins - genetics Autophagy Autophagy (Cytology) Autophagy - drug effects Bcl-2 protein Beclin-1 Biochemistry Biology Brain Brain - blood supply Brain - drug effects Brain - pathology Brain injury Brain Ischemia - genetics Brain Ischemia - pathology Brain Ischemia - prevention & control Brain research Care and treatment Carotid artery Causes of Cell death Cerebral blood flow Cerebral ischemia Diagnosis Edema Endoplasmic reticulum Homeostasis Hypoxia Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Inhibition Injury prevention Ischemia Ischemic Postconditioning - methods Male Medicine Microtubule-Associated Proteins - genetics Molecular biology Neurology Neuroprotection Occlusion Phagocytosis Phagosomes Pharmacology Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Rapamycin Rats Rats, Sprague-Dawley Reperfusion Rodents Sirolimus - pharmacology Sirolimus - therapeutic use Stroke Up-Regulation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!