Inhibition of fatty acid metabolism reduces human myeloma cells proliferation

Multiple myeloma is a haematological malignancy characterized by the clonal proliferation of plasma cells. It has been proposed that targeting cancer cell metabolism would provide a new selective anticancer therapeutic strategy. In this work, we tested the hypothesis that inhibition of β-oxidation a...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e46484
Hauptverfasser:	Tirado-Vélez, José Manuel, Joumady, Insaf, Sáez-Benito, Ana, Cózar-Castellano, Irene, Perdomo, Germán
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - pharmacology Apoptosis Apoptosis - drug effects Biology Boronic Acids - pharmacology Bortezomib Cancer Carbohydrate Metabolism - drug effects Cell cycle Cell Cycle Proteins - metabolism Cell death Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cerulenin - pharmacology Cyclin-Dependent Kinase Inhibitor p21 - metabolism Drug Synergism Drugs Epoxy Compounds - pharmacology Fatty acid metabolism Fatty acids Fatty Acids - biosynthesis Fatty Acids - metabolism G1 Phase Cell Cycle Checkpoints - drug effects Glucose Glucose - metabolism GTP-binding protein Hematology Humans Inhibition Kinases Lactones - pharmacology Lipid Metabolism - drug effects Lipids Malignancy Medicine Metabolism Multiple Myeloma Oxidation Oxidation-Reduction Phosphorylation Plasma cells Proteins Pyrazines - pharmacology Regulatory proteins Retina Retinoblastoma Retinoblastoma protein Retinoblastoma Protein - metabolism Rodents S phase Synthesis
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