Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy
Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of H...
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| Veröffentlicht in: | PloS one 2012-09, Vol.7 (9), p.e45291-e45291 |
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| creator | Anraku, Itaru Rajasuriar, Reena Dobbin, Caroline Brown, Richard Lewin, Sharon R Suhrbier, Andreas |
| description | Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients. |
| doi_str_mv | 10.1371/journal.pone.0045291 |
| format | Article |
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To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0045291</identifier><identifier>PMID: 23028910</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Adult ; AIDS ; Anti-inflammatory agents ; Anti-Retroviral Agents - therapeutic use ; Antiretroviral agents ; Antiretroviral drugs ; Antiretroviral Therapy, Highly Active ; Apoptosis ; Arthritis ; Biological products ; Biomarkers ; Cardiovascular disease ; Care and treatment ; CD14 antigen ; CD4 antigen ; CD4 Lymphocyte Count ; Chaperonin 10 - blood ; Chaperonin 10 - genetics ; Chaperonin 10 - immunology ; Chaperonin 60 - blood ; Chaperonin 60 - genetics ; Chaperonin 60 - immunology ; Cytokines ; Dosage and administration ; Drug therapy ; Female ; Gene Expression ; Health aspects ; Heat shock proteins ; Hepatitis ; Hepatitis C ; HIV ; HIV - drug effects ; HIV - physiology ; HIV Infections - blood ; HIV Infections - drug therapy ; HIV Infections - immunology ; HIV Infections - virology ; HIV patients ; Hsp60 protein ; Human immunodeficiency virus ; Humans ; Immune response ; Infections ; Infectious diseases ; Inflammation ; Lipopolysaccharide Receptors - blood ; Lipopolysaccharides ; Lipopolysaccharides - blood ; Male ; Medical research ; Medicine ; Middle Aged ; Mitochondria ; Patients ; Plasma levels ; Proteins ; Rodents ; Statistical analysis ; Therapy ; Viral Load - drug effects</subject><ispartof>PloS one, 2012-09, Vol.7 (9), p.e45291-e45291</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Anraku et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Anraku et al 2012 Anraku et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-153827e28a44b8f94490cf7abb2105b4cfbb9cdea2abcec8288763ad5b0621883</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460931/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460931/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23028910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Buch, Shilpa J.</contributor><creatorcontrib>Anraku, Itaru</creatorcontrib><creatorcontrib>Rajasuriar, Reena</creatorcontrib><creatorcontrib>Dobbin, Caroline</creatorcontrib><creatorcontrib>Brown, Richard</creatorcontrib><creatorcontrib>Lewin, Sharon R</creatorcontrib><creatorcontrib>Suhrbier, Andreas</creatorcontrib><title>Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adult</subject><subject>AIDS</subject><subject>Anti-inflammatory agents</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Antiretroviral agents</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Apoptosis</subject><subject>Arthritis</subject><subject>Biological products</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>CD14 antigen</subject><subject>CD4 antigen</subject><subject>CD4 Lymphocyte Count</subject><subject>Chaperonin 10 - blood</subject><subject>Chaperonin 10 - genetics</subject><subject>Chaperonin 10 - immunology</subject><subject>Chaperonin 60 - blood</subject><subject>Chaperonin 60 - genetics</subject><subject>Chaperonin 60 - immunology</subject><subject>Cytokines</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Health aspects</subject><subject>Heat shock proteins</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>HIV</subject><subject>HIV - drug effects</subject><subject>HIV - physiology</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - virology</subject><subject>HIV patients</subject><subject>Hsp60 protein</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune response</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Lipopolysaccharide Receptors - blood</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mitochondria</subject><subject>Patients</subject><subject>Plasma levels</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Statistical analysis</subject><subject>Therapy</subject><subject>Viral Load - 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To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23028910</pmid><doi>10.1371/journal.pone.0045291</doi><tpages>e45291</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acquired immune deficiency syndrome Adult AIDS Anti-inflammatory agents Anti-Retroviral Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral Therapy, Highly Active Apoptosis Arthritis Biological products Biomarkers Cardiovascular disease Care and treatment CD14 antigen CD4 antigen CD4 Lymphocyte Count Chaperonin 10 - blood Chaperonin 10 - genetics Chaperonin 10 - immunology Chaperonin 60 - blood Chaperonin 60 - genetics Chaperonin 60 - immunology Cytokines Dosage and administration Drug therapy Female Gene Expression Health aspects Heat shock proteins Hepatitis Hepatitis C HIV HIV - drug effects HIV - physiology HIV Infections - blood HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV patients Hsp60 protein Human immunodeficiency virus Humans Immune response Infections Infectious diseases Inflammation Lipopolysaccharide Receptors - blood Lipopolysaccharides Lipopolysaccharides - blood Male Medical research Medicine Middle Aged Mitochondria Patients Plasma levels Proteins Rodents Statistical analysis Therapy Viral Load - drug effects |
| title | Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy |
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