DNA vaccination partially protects against African swine fever virus lethal challenge in the absence of antibodies

The lack of available vaccines against African swine fever virus (ASFV) means that the evaluation of new immunization strategies is required. Here we show that fusion of the extracellular domain of the ASFV Hemagglutinin (sHA) to p54 and p30, two immunodominant structural viral antigens, exponential...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e40942-e40942
Hauptverfasser:	Argilaguet, Jordi M, Pérez-Martín, Eva, Nofrarías, Miquel, Gallardo, Carmina, Accensi, Francesc, Lacasta, Anna, Mora, Mercedes, Ballester, Maria, Galindo-Cardiel, Ivan, López-Soria, Sergio, Escribano, José M, Reche, Pedro A, Rodríguez, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	African swine fever African Swine Fever - immunology African Swine Fever - mortality African Swine Fever - prevention & control African Swine Fever - virology African Swine Fever Virus - immunology Animals Antibodies Antibodies, Viral - immunology Antigen presentation Antigens Antigens, Viral - genetics Antigens, Viral - immunology Asfarviridae Biology CD8 antigen Cells, Cultured Cellular structure Cytotoxicity Deoxyribonucleic acid Disease DNA DNA vaccines DNA, Viral - genetics DNA, Viral - immunology Experiments Fever Hemagglutinins Hogs Immunization Immunoglobulins Interferon-gamma - immunology Interferon-gamma - secretion Livestock Lymphocytes T Medicine Peptides Plasmids Plasmids - genetics Plasmids - immunology Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Survival Rate Swine T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Ubiquitin Ubiquitin - genetics Ubiquitin - immunology Vaccination Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccines, Synthetic Veterinary Science Viral Proteins - genetics Viral Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology Viremia Viruses γ-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!