Violacein induces death of resistant leukaemia cells via kinome reprogramming, endoplasmic reticulum stress and Golgi apparatus collapse

It is now generally recognised that different modes of programmed cell death (PCD) are intimately linked to the cancerous process. However, the mechanism of PCD involved in cancer chemoprevention is much less clear and may be different between types of chemopreventive agents and tumour cell types in...

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Veröffentlicht in:	PloS one 2012-10, Vol.7 (10), p.e45362-e45362
Hauptverfasser:	Queiroz, Karla C S, Milani, Renato, Ruela-de-Sousa, Roberta R, Fuhler, Gwenny M, Justo, Giselle Z, Zambuzzi, Willian F, Duran, Nelson, Diks, Sander H, Spek, C Arnold, Ferreira, Carmen V, Peppelenbosch, Maikel P
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Antibiotics Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - antagonists & inhibitors Autophagy Biochemistry Bioengineering Biology Biomarkers c-Kit protein Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors Calpain Calpain - antagonists & inhibitors Cancer Cancer prevention Cancer therapies Care and treatment CD34 antigen Cell adhesion & migration Cell death Cell Death - drug effects Cell Line, Tumor Cell Survival - drug effects Cells (biology) Chemopreventive agents Chemotherapy Chromobacterium Collapse Colorectal cancer Cyclic AMP-Dependent Protein Kinases - metabolism Cytotoxicity Death-associated protein kinase Death-Associated Protein Kinases Drug development Endoplasmic reticulum Endoplasmic Reticulum Stress Gastroenterology Glycoproteins Golgi apparatus Golgi Apparatus - drug effects Hepatology Humans Immunoglobulins Indoles - therapeutic use Kinases Leukemia Leukemia - drug therapy Medical research Medicine Mortality P-Glycoprotein Phagocytosis Pharmacology Protein kinase A Proteins Proto-Oncogene Proteins c-akt - metabolism Rivers Rodents Signal transduction Signaling Stem cells Tumors Violacein
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