The schizophrenia-associated Kv11.1-3.1 isoform results in reduced current accumulation during repetitive brief depolarizations

Recent genome wide association studies identified a brain and primate specific isoform of a voltage-gated potassium channel, referred to as Kv11.1-3.1, which is significantly associated with schizophrenia. The 3.1 isoform replaces the first 102 amino acids of the most abundant isoform (referred to a...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45624-e45624
Hauptverfasser:	Heide, Juliane, Mann, Stefan A, Vandenberg, Jamie I
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Action potential Action Potentials Amino acids Analysis Animals Base Sequence Biology Brain Brain research Channel gating CHO Cells Cricetinae Cricetulus Deactivation Depolarization Diagnosis Digitization DNA Primers Electric potential Ether-A-Go-Go Potassium Channels - chemistry Ether-A-Go-Go Potassium Channels - physiology Experiments Gene expression Genome-wide association studies Genomes Humans Inactivation Ion Channel Gating Kinetics Medicine Mental disorders Potassium Potassium channels (voltage-gated) Protein Isoforms - chemistry Protein Isoforms - physiology Psychiatry Risk factors Schizophrenia Schizophrenia - physiopathology Single nucleotide polymorphisms Studies
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