Prenatal exposure to TCDD triggers significant modulation of microRNA expression profile in the thymus that affects consequent gene expression

MicroRNAs (miRs) are a class of small RNAs that regulate gene expression. There are over 700 miRs encoded in the mouse genome and modulate most of the cellular pathways and functions by controlling gene expression. However, there is not much known about the pathophysiological role of miRs. TCDD (2,3...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45054
Hauptverfasser:	Singh, Narendra P, Singh, Udai P, Guan, Hongbing, Nagarkatti, Prakash, Nagarkatti, Mitzi
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Analysis Animal genetics Animals Apoptosis Apoptosis - drug effects Apoptosis - genetics Atrophy Biology Biomarkers Cancer Cell cycle Cell differentiation Cluster Analysis Contaminants Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Cytochrome P450 Differentiation (biology) Dioxins Disease susceptibility Environmental stress Enzymes Exposure Fas Ligand Protein - genetics Fas Ligand Protein - metabolism fas Receptor - genetics fas Receptor - metabolism FasL protein Female Fetal alcohol syndrome Fetuses Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental - drug effects Gene Regulatory Networks Genes Genomes Genomics Herbicides Hydrocarbons Immunology Intrauterine exposure Long-term effects Lymphocytes T Maternal Exposure Medicine Mice MicroRNA MicroRNAs MicroRNAs - genetics miRNA Neoplasms - genetics Nutrient deficiency Pathology Pathways Polychlorinated Dibenzodioxins - pharmacology Polychlorinated Dibenzodioxins - toxicity Polymerase chain reaction Pregnancy Pregnant women Prenatal experience Prenatal exposure Prostate cancer Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Reproducibility of Results Ribonucleic acid RNA Rodents Signal Transduction - drug effects T cells TCDD Thymocytes Thymocytes - drug effects Thymocytes - metabolism Thymus Thymus Gland - drug effects Thymus Gland - embryology Thymus Gland - metabolism Toxicity
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