Discovery and characterization of human exonic transcriptional regulatory elements

We sought exonic transcriptional regulatory elements by shotgun cloning human cDNA fragments into luciferase reporter vectors and measuring the resulting expression levels in liver cells. We uncovered seven regulatory elements within coding regions and three within 3' untranslated regions (UTRs...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e46098-e46098
Hauptverfasser:	Khan, Arshad H, Lin, Andy, Smith, Desmond J
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Binding Sites Biology Cell Line Chromatin Chromatin - genetics Chromatin - metabolism Cloning Cloning vectors Deoxyribonuclease I - metabolism Deoxyribonucleic acid DNA DNA, Complementary - genetics Enhancers Expression vectors Gene expression Gene sequencing Genome, Human Genomes Genomics Hepatocytes Histones - genetics Histones - metabolism Humans Liver Pharmacology Proteins Regulatory Elements, Transcriptional Regulatory sequences RNA polymerase Rodents Silencers Transcription factors Transcription Factors - metabolism Tubulin Tubulin - genetics
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