Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase
Cognitive performance deteriorates during extended wakefulness and circadian phase misalignment, and some individuals are more affected than others. Whether performance is affected similarly across cognitive domains, or whether cognitive processes involving Executive Functions are more sensitive to...
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| Veröffentlicht in: | PloS one 2012-09, Vol.7 (9), p.e45987-e45987 |
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| creator | Lo, June C Groeger, John A Santhi, Nayantara Arbon, Emma L Lazar, Alpar S Hasan, Sibah von Schantz, Malcolm Archer, Simon N Dijk, Derk-Jan |
| description | Cognitive performance deteriorates during extended wakefulness and circadian phase misalignment, and some individuals are more affected than others. Whether performance is affected similarly across cognitive domains, or whether cognitive processes involving Executive Functions are more sensitive to sleep and circadian misalignment than Alertness and Sustained Attention, is a matter of debate.
We conducted a 2 × 12-day laboratory protocol to characterize the interaction of repeated partial and acute total sleep deprivation and circadian phase on performance across seven cognitive domains in 36 individuals (18 males; mean ± SD of age = 27.6 ± 4.0 years). The sample was stratified for the rs57875989 polymorphism in PER3, which confers cognitive susceptibility to total sleep deprivation. We observed a deterioration of performance during both repeated partial and acute total sleep deprivation. Furthermore, prior partial sleep deprivation led to poorer cognitive performance in a subsequent total sleep deprivation period, but its effect was modulated by circadian phase such that it was virtually absent in the evening wake maintenance zone, and most prominent during early morning hours. A significant effect of PER3 genotype was observed for Subjective Alertness during partial sleep deprivation and on n-back tasks with a high executive load when assessed in the morning hours during total sleep deprivation after partial sleep loss. Overall, however, Subjective Alertness and Sustained Attention were more affected by both partial and total sleep deprivation than other cognitive domains and tasks including n-back tasks of Working Memory, even when implemented with a high executive load.
Sleep loss has a primary effect on Sleepiness and Sustained Attention with much smaller effects on challenging Working Memory tasks. These findings have implications for understanding how sleep debt and circadian rhythmicity interact to determine waking performance across cognitive domains and individuals. |
| doi_str_mv | 10.1371/journal.pone.0045987 |
| format | Article |
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We conducted a 2 × 12-day laboratory protocol to characterize the interaction of repeated partial and acute total sleep deprivation and circadian phase on performance across seven cognitive domains in 36 individuals (18 males; mean ± SD of age = 27.6 ± 4.0 years). The sample was stratified for the rs57875989 polymorphism in PER3, which confers cognitive susceptibility to total sleep deprivation. We observed a deterioration of performance during both repeated partial and acute total sleep deprivation. Furthermore, prior partial sleep deprivation led to poorer cognitive performance in a subsequent total sleep deprivation period, but its effect was modulated by circadian phase such that it was virtually absent in the evening wake maintenance zone, and most prominent during early morning hours. A significant effect of PER3 genotype was observed for Subjective Alertness during partial sleep deprivation and on n-back tasks with a high executive load when assessed in the morning hours during total sleep deprivation after partial sleep loss. Overall, however, Subjective Alertness and Sustained Attention were more affected by both partial and total sleep deprivation than other cognitive domains and tasks including n-back tasks of Working Memory, even when implemented with a high executive load.
Sleep loss has a primary effect on Sleepiness and Sustained Attention with much smaller effects on challenging Working Memory tasks. These findings have implications for understanding how sleep debt and circadian rhythmicity interact to determine waking performance across cognitive domains and individuals.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0045987</identifier><identifier>PMID: 23029352</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alertness ; Analysis ; Biochemistry ; Biology ; Brain research ; Care and treatment ; Circadian Rhythm ; Circadian rhythms ; Cognition ; Cognitive ability ; Cognitive tasks ; Complications and side effects ; Executive Function ; Experiments ; Female ; Genetic aspects ; Health aspects ; Humans ; Intelligence (Psychology) ; Male ; Males ; Medical research ; Medicine ; Memory ; Memory tasks ; Memory, Short-Term ; Mental task performance ; Misalignment ; Morning ; Period 3 protein ; Period Circadian Proteins - genetics ; Physiology ; Polymorphism ; Polymorphism, Single Nucleotide ; Psychomotor Performance ; Short term memory ; Sleep ; Sleep and wakefulness ; Sleep deprivation ; Sleep Deprivation - complications ; Sleep Deprivation - genetics ; Sleepiness ; Social and Behavioral Sciences ; Studies ; Wakefulness ; Young Adult</subject><ispartof>PloS one, 2012-09, Vol.7 (9), p.e45987-e45987</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Lo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Lo et al 2012 Lo et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-d77c9ef707b53a4564f4d3971bb53358b9cbbc2d28ebafeece28955eabfdceb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454374/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3454374/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23029352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yamazaki, Shin</contributor><creatorcontrib>Lo, June C</creatorcontrib><creatorcontrib>Groeger, John A</creatorcontrib><creatorcontrib>Santhi, Nayantara</creatorcontrib><creatorcontrib>Arbon, Emma L</creatorcontrib><creatorcontrib>Lazar, Alpar S</creatorcontrib><creatorcontrib>Hasan, Sibah</creatorcontrib><creatorcontrib>von Schantz, Malcolm</creatorcontrib><creatorcontrib>Archer, Simon N</creatorcontrib><creatorcontrib>Dijk, Derk-Jan</creatorcontrib><title>Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Cognitive performance deteriorates during extended wakefulness and circadian phase misalignment, and some individuals are more affected than others. Whether performance is affected similarly across cognitive domains, or whether cognitive processes involving Executive Functions are more sensitive to sleep and circadian misalignment than Alertness and Sustained Attention, is a matter of debate.
We conducted a 2 × 12-day laboratory protocol to characterize the interaction of repeated partial and acute total sleep deprivation and circadian phase on performance across seven cognitive domains in 36 individuals (18 males; mean ± SD of age = 27.6 ± 4.0 years). The sample was stratified for the rs57875989 polymorphism in PER3, which confers cognitive susceptibility to total sleep deprivation. We observed a deterioration of performance during both repeated partial and acute total sleep deprivation. Furthermore, prior partial sleep deprivation led to poorer cognitive performance in a subsequent total sleep deprivation period, but its effect was modulated by circadian phase such that it was virtually absent in the evening wake maintenance zone, and most prominent during early morning hours. A significant effect of PER3 genotype was observed for Subjective Alertness during partial sleep deprivation and on n-back tasks with a high executive load when assessed in the morning hours during total sleep deprivation after partial sleep loss. Overall, however, Subjective Alertness and Sustained Attention were more affected by both partial and total sleep deprivation than other cognitive domains and tasks including n-back tasks of Working Memory, even when implemented with a high executive load.
Sleep loss has a primary effect on Sleepiness and Sustained Attention with much smaller effects on challenging Working Memory tasks. 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tasks</subject><subject>Memory, Short-Term</subject><subject>Mental task performance</subject><subject>Misalignment</subject><subject>Morning</subject><subject>Period 3 protein</subject><subject>Period Circadian Proteins - genetics</subject><subject>Physiology</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psychomotor Performance</subject><subject>Short term memory</subject><subject>Sleep</subject><subject>Sleep and wakefulness</subject><subject>Sleep deprivation</subject><subject>Sleep Deprivation - complications</subject><subject>Sleep Deprivation - genetics</subject><subject>Sleepiness</subject><subject>Social and Behavioral Sciences</subject><subject>Studies</subject><subject>Wakefulness</subject><subject>Young 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One</addtitle><date>2012-09-24</date><risdate>2012</risdate><volume>7</volume><issue>9</issue><spage>e45987</spage><epage>e45987</epage><pages>e45987-e45987</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Cognitive performance deteriorates during extended wakefulness and circadian phase misalignment, and some individuals are more affected than others. Whether performance is affected similarly across cognitive domains, or whether cognitive processes involving Executive Functions are more sensitive to sleep and circadian misalignment than Alertness and Sustained Attention, is a matter of debate.
We conducted a 2 × 12-day laboratory protocol to characterize the interaction of repeated partial and acute total sleep deprivation and circadian phase on performance across seven cognitive domains in 36 individuals (18 males; mean ± SD of age = 27.6 ± 4.0 years). The sample was stratified for the rs57875989 polymorphism in PER3, which confers cognitive susceptibility to total sleep deprivation. We observed a deterioration of performance during both repeated partial and acute total sleep deprivation. Furthermore, prior partial sleep deprivation led to poorer cognitive performance in a subsequent total sleep deprivation period, but its effect was modulated by circadian phase such that it was virtually absent in the evening wake maintenance zone, and most prominent during early morning hours. A significant effect of PER3 genotype was observed for Subjective Alertness during partial sleep deprivation and on n-back tasks with a high executive load when assessed in the morning hours during total sleep deprivation after partial sleep loss. Overall, however, Subjective Alertness and Sustained Attention were more affected by both partial and total sleep deprivation than other cognitive domains and tasks including n-back tasks of Working Memory, even when implemented with a high executive load.
Sleep loss has a primary effect on Sleepiness and Sustained Attention with much smaller effects on challenging Working Memory tasks. These findings have implications for understanding how sleep debt and circadian rhythmicity interact to determine waking performance across cognitive domains and individuals.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23029352</pmid><doi>10.1371/journal.pone.0045987</doi><tpages>e45987</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-09, Vol.7 (9), p.e45987-e45987 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; PMC (PubMed Central); DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Adult Alertness Analysis Biochemistry Biology Brain research Care and treatment Circadian Rhythm Circadian rhythms Cognition Cognitive ability Cognitive tasks Complications and side effects Executive Function Experiments Female Genetic aspects Health aspects Humans Intelligence (Psychology) Male Males Medical research Medicine Memory Memory tasks Memory, Short-Term Mental task performance Misalignment Morning Period 3 protein Period Circadian Proteins - genetics Physiology Polymorphism Polymorphism, Single Nucleotide Psychomotor Performance Short term memory Sleep Sleep and wakefulness Sleep deprivation Sleep Deprivation - complications Sleep Deprivation - genetics Sleepiness Social and Behavioral Sciences Studies Wakefulness Young Adult |
| title | Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T23%3A30%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20partial%20and%20acute%20total%20sleep%20deprivation%20on%20performance%20across%20cognitive%20domains,%20individuals%20and%20circadian%20phase&rft.jtitle=PloS%20one&rft.au=Lo,%20June%20C&rft.date=2012-09-24&rft.volume=7&rft.issue=9&rft.spage=e45987&rft.epage=e45987&rft.pages=e45987-e45987&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0045987&rft_dat=%3Cgale_plos_%3EA498252126%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1326547584&rft_id=info:pmid/23029352&rft_galeid=A498252126&rft_doaj_id=oai_doaj_org_article_f9a2a2d2ddbd4ea68a2312b687329a65&rfr_iscdi=true |