HtrA3 as an early marker for preeclampsia: specific monoclonal antibodies and sensitive high-throughput assays for serum screening

Mammalian HtrA3 (high temperature requirement A3) is a serine protease of the HtrA family. It has two isoforms [long (HtrA3-L) and short (HtrA3-S)] and is important for placental development and cancer progression. Recently, HtrA3 was identified as a potential diagnostic marker for early detection o...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45956
Hauptverfasser:	Dynon, Kemperly, Heng, Sophea, Puryer, Michelle, Li, Ying, Walton, Kelly, Endo, Yaeta, Nie, Guiying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antibodies, Monoclonal - chemistry Assaying Biological assay Biology Cancer Cardiovascular disease Diagnosis Diagnostic systems DNA methylation Endometrium - metabolism Epitope Mapping - methods Epitopes - chemistry Female Genetic aspects Gestation Gestational Age Health aspects High temperature Human tissues Humans Hypertension Immunoassay Immunoassay - methods Immunoassays Innovations Insulin Isoforms Mammals Medical research Medicine Mice Mice, Inbred C57BL Mice, Knockout Monoclonal antibodies Ovarian cancer Placenta Pre-eclampsia Pre-Eclampsia - diagnosis Pre-Eclampsia - metabolism Preeclampsia Pregnancy Pregnancy Trimester, Second Proteases Protein Isoforms Protein Structure, Tertiary Proteins Recombinant Proteins - chemistry Screening Serine Serine Endopeptidases - metabolism Serine proteinase Serum levels Stroke Systematic review Temperature requirements Tissue Distribution Tissues Trophoblasts - cytology Uterus - metabolism Western blotting Womens health
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