Specific acquisition of functional CD59 but not CD46 or CD55 by hepatitis C virus

Viruses of different families encode for regulators of the complement system (RCAs) or acquire such RCAs from the host to get protection against complement-mediated lysis (CML). As hepatitis C virus (HCV) shares no genetic similarity to any known RCA and is detectable at high titers in sera of infec...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45770-e45770
Hauptverfasser:	Ejaz, Asim, Steinmann, Eike, Bánki, Zoltán, Anggakusuma, Khalid, Sana, Lengauer, Susanne, Wilhelm, Corinne, Zoller, Heinz, Schloegl, Anna, Steinmann, Joerg, Grabski, Elena, Kleines, Michael, Pietschmann, Thomas, Stoiber, Heribert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies Biology CD46 antigen CD55 Antigens - metabolism CD59 antigen CD59 Antigens - metabolism Cell culture Cell Line Cell Line, Tumor Complement Complement Activation Complement Inactivator Proteins - immunology Complement system Complement System Proteins Dendritic cells Female Flow Cytometry - methods Gastroenterology Genetic aspects Genotype Hepacivirus - metabolism Hepatitis Hepatitis C Hepatitis C virus Hepatology HIV Hospitals Human immunodeficiency virus Humans Immunoglobulin G - chemistry Infections Infectivity Liver cancer Lysis Male Medicine Membrane Cofactor Protein - metabolism Middle Aged Proteins Regulators Risk factors Signal transduction Viral infections Virology Viruses
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