Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), remains the leading cause of mortality from a single infectious agent. Each year around 9 million individuals newly develop active TB disease, and over 2 billion individuals are latently infected with M.tb worldwide, thus being at risk...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e45839-e45839
Hauptverfasser:	Ottenhoff, Tom H M, Dass, Ranjeeta Hari, Yang, Ninghan, Zhang, Mingzi M, Wong, Hazel E E, Sahiratmadja, Edhyana, Khor, Chiea Chuen, Alisjahbana, Bachti, van Crevel, Reinout, Marzuki, Sangkot, Seielstad, Mark, van de Vosse, Esther, Hibberd, Martin L
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adult Animal models Animals Autophagy Biology Blood Case-Control Studies Cell Line Cluster Analysis Cytokines Enzymes Epidemiology Female Gene expression Gene Expression Profiling Gene Expression Regulation Genome, Human Genomes Health risks Host-Pathogen Interactions Humans Indonesia Infections Infectious diseases Interferon Interferon Type I - genetics Interferon Type I - metabolism Interleukin 1 Latent infection Longitudinal Studies Lung - metabolism Lungs Lymphocytes Macrophages Male Medical research Medicine Metabolic Networks and Pathways - genetics Metabolic Networks and Pathways - immunology Mice Mice, Inbred C57BL Mycobacterium tuberculosis Mycobacterium tuberculosis - physiology Myeloid cells Oligonucleotide Array Sequence Analysis Patients Proteins Sarcoidosis Signal transduction Signaling Studies Transcriptome Tuberculosis Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - immunology γ-Interferon
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