Altered protein expression in gestational diabetes mellitus placentas provides insight into insulin resistance and coagulation/fibrinolysis pathways

To investigate the placental proteome differences between pregnant women complicated with gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT). We used two-dimensional electrophoresis (2DE) to separate and compare placental protein levels from GDM and NGT groups. Differe...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e44701-e44701
Hauptverfasser:	Liu, Bin, Xu, Yun, Voss, Courtney, Qiu, Fang-hua, Zhao, Ming-zhe, Liu, Yong-dong, Nie, Jing, Wang, Zi-lian
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein Adult Annexins Anticoagulants Apoptosis Atherosclerosis Binding Biology Blood Coagulation Calcium Calcium ions Cellular signal transduction Coagulation Diabetes Diabetes mellitus Dimensional tolerances Electrophoresis, Gel, Two-Dimensional Endocrinology Female Fibrinolysis Gene expression Gestational diabetes Glucose Glucose tolerance Gynecology Hospitals Humans Hyperglycemia Immunohistochemistry Insulin Insulin Resistance Mass spectrometry Mass spectroscopy Medicine Metabolism mRNA Obstetrics Pathogenesis Phospholipids Placenta Placenta - metabolism Polymerase chain reaction Pregnancy Pregnant women Protein expression Proteins Proteins - genetics Proteins - isolation & purification Proteins - metabolism Proteomes Proteomics Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectroscopy Tandem Mass Spectrometry Transfer RNA tRNA Trp Tryptophan Tryptophan-tRNA ligase Type 2 diabetes Western blotting Womens health
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