Prolactin stimulates precursor cells in the adult mouse hippocampus

In the search for ways to combat degenerative neurological disorders, neurogenesis-stimulating factors are proving to be a promising area of research. In this study, we show that the hormonal factor prolactin (PRL) can activate a pool of latent precursor cells in the adult mouse hippocampus. Using a...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e44371
Hauptverfasser:	Walker, Tara L, Vukovic, Jana, Koudijs, Margaretha M, Blackmore, Daniel G, Mackay, Eirinn W, Sykes, Alex M, Overall, Rupert W, Hamlin, Adam S, Bartlett, Perry F
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biology Blotting, Western Brain Brain research Bromodeoxyuridine Cell Count Cell Differentiation - physiology Dentate gyrus Dentate Gyrus - drug effects Dentate Gyrus - physiology Endocrinology Females Growth factors Hippocampus Hippocampus - cytology Hormones Immunohistochemistry In Vitro Techniques In vivo methods and tests Learning Learning - drug effects Medicine Memory Memory - drug effects Mice Mice, Inbred C57BL Microarray Analysis Neural networks Neural Stem Cells - drug effects Neural Stem Cells - physiology Neurogenesis Neurogenesis - drug effects Neurological diseases Neurons Neuropsychological Tests Neurospheres Octoxynol Pheromones Precursors Prolactin Prolactin - pharmacology Rodents Stem cells
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