Development and validation of a new questionnaire assessing quality of life in adults with hypopituitarism: Adult Hypopituitarism Questionnaire (AHQ)
To develop and validate the Adult Hypopituitarism Questionnaire (AHQ) as a disease-specific, self-administered questionnaire for evaluation of quality of life (QOL) in adult patients with hypopituitarism. We developed and validated this new questionnaire, using a standardized procedure which include...
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| Veröffentlicht in: | PloS one 2012-09, Vol.7 (9), p.e44304-e44304 |
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| creator | Ishii, Hitoshi Shimatsu, Akira Okimura, Yasuhiko Tanaka, Toshiaki Hizuka, Naomi Kaji, Hidesuke Hanew, Kunihiko Oki, Yutaka Yamashiro, Sayuri Takano, Koji Chihara, Kazuo |
| description | To develop and validate the Adult Hypopituitarism Questionnaire (AHQ) as a disease-specific, self-administered questionnaire for evaluation of quality of life (QOL) in adult patients with hypopituitarism.
We developed and validated this new questionnaire, using a standardized procedure which included item development, pilot-testing and psychometric validation. Of the patients who participated in psychometric validation, those whose clinical conditions were judged to be stable were asked to answer the survey questionnaire twice, in order to assess test-retest reliability.
Content validity of the initial questionnaire was evaluated via two pilot tests. After these tests, we made minor revisions and finalized the initial version of the questionnaire. The questionnaire was constructed with two domains, one psycho-social and the other physical. For psychometric assessment, analyses were performed on the responses of 192 adult patients with various types of hypopituitarism. The intraclass correlations of the respective domains were 0.91 and 0.95, and the Cronbach's alpha coefficients were 0.96 and 0.95, indicating adequate test-retest reliability and internal consistency for each domain. For known-group validity, patients with hypopituitarism due to hypothalamic disorder showed significantly lower scores in 11 out of 13 sub-domains compared to those who had hypopituitarism due to pituitary disorder. Regarding construct validity, the domain structure was found to be almost the same as that initially hypothesized. Exploratory factor analysis (n = 228) demonstrated that each domain consisted of six and seven sub-domains.
The AHQ showed good reliability and validity for evaluating QOL in adult patients with hypopituitarism. |
| doi_str_mv | 10.1371/journal.pone.0044304 |
| format | Article |
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We developed and validated this new questionnaire, using a standardized procedure which included item development, pilot-testing and psychometric validation. Of the patients who participated in psychometric validation, those whose clinical conditions were judged to be stable were asked to answer the survey questionnaire twice, in order to assess test-retest reliability.
Content validity of the initial questionnaire was evaluated via two pilot tests. After these tests, we made minor revisions and finalized the initial version of the questionnaire. The questionnaire was constructed with two domains, one psycho-social and the other physical. For psychometric assessment, analyses were performed on the responses of 192 adult patients with various types of hypopituitarism. The intraclass correlations of the respective domains were 0.91 and 0.95, and the Cronbach's alpha coefficients were 0.96 and 0.95, indicating adequate test-retest reliability and internal consistency for each domain. For known-group validity, patients with hypopituitarism due to hypothalamic disorder showed significantly lower scores in 11 out of 13 sub-domains compared to those who had hypopituitarism due to pituitary disorder. Regarding construct validity, the domain structure was found to be almost the same as that initially hypothesized. Exploratory factor analysis (n = 228) demonstrated that each domain consisted of six and seven sub-domains.
The AHQ showed good reliability and validity for evaluating QOL in adult patients with hypopituitarism.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0044304</identifier><identifier>PMID: 22984490</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Aged ; Aged, 80 and over ; Analysis ; Cognition ; Cohort Studies ; Diabetes ; Endocrinology ; Factor analysis ; Factor Analysis, Statistical ; Female ; Growth hormones ; Hospitals ; Humans ; Hypopituitarism ; Hypopituitarism - physiopathology ; Hypothalamus ; Interviews ; Male ; Medicine ; Metabolism ; Middle Aged ; Patients ; Pituitary ; Psychometrics ; Qualitative research ; Quality assessment ; Quality of Life ; Quantitative psychology ; Questionnaires ; Reliability analysis ; Reproducibility of Results ; Social and Behavioral Sciences ; Surveys ; Surveys and Questionnaires - standards ; Validity ; Young Adult</subject><ispartof>PloS one, 2012-09, Vol.7 (9), p.e44304-e44304</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Ishii et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Ishii et al 2012 Ishii et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d078841cec756d2e4fbe1bcf8668dc09d61d6d8b1c8183501908dd88eb7f6a313</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439490/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439490/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22984490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Heaton, Robert K.</contributor><creatorcontrib>Ishii, Hitoshi</creatorcontrib><creatorcontrib>Shimatsu, Akira</creatorcontrib><creatorcontrib>Okimura, Yasuhiko</creatorcontrib><creatorcontrib>Tanaka, Toshiaki</creatorcontrib><creatorcontrib>Hizuka, Naomi</creatorcontrib><creatorcontrib>Kaji, Hidesuke</creatorcontrib><creatorcontrib>Hanew, Kunihiko</creatorcontrib><creatorcontrib>Oki, Yutaka</creatorcontrib><creatorcontrib>Yamashiro, Sayuri</creatorcontrib><creatorcontrib>Takano, Koji</creatorcontrib><creatorcontrib>Chihara, Kazuo</creatorcontrib><title>Development and validation of a new questionnaire assessing quality of life in adults with hypopituitarism: Adult Hypopituitarism Questionnaire (AHQ)</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To develop and validate the Adult Hypopituitarism Questionnaire (AHQ) as a disease-specific, self-administered questionnaire for evaluation of quality of life (QOL) in adult patients with hypopituitarism.
We developed and validated this new questionnaire, using a standardized procedure which included item development, pilot-testing and psychometric validation. Of the patients who participated in psychometric validation, those whose clinical conditions were judged to be stable were asked to answer the survey questionnaire twice, in order to assess test-retest reliability.
Content validity of the initial questionnaire was evaluated via two pilot tests. After these tests, we made minor revisions and finalized the initial version of the questionnaire. The questionnaire was constructed with two domains, one psycho-social and the other physical. For psychometric assessment, analyses were performed on the responses of 192 adult patients with various types of hypopituitarism. The intraclass correlations of the respective domains were 0.91 and 0.95, and the Cronbach's alpha coefficients were 0.96 and 0.95, indicating adequate test-retest reliability and internal consistency for each domain. For known-group validity, patients with hypopituitarism due to hypothalamic disorder showed significantly lower scores in 11 out of 13 sub-domains compared to those who had hypopituitarism due to pituitary disorder. Regarding construct validity, the domain structure was found to be almost the same as that initially hypothesized. Exploratory factor analysis (n = 228) demonstrated that each domain consisted of six and seven sub-domains.
The AHQ showed good reliability and validity for evaluating QOL in adult patients with hypopituitarism.</description><subject>Adult</subject><subject>Adults</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Cognition</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Factor analysis</subject><subject>Factor Analysis, Statistical</subject><subject>Female</subject><subject>Growth hormones</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypopituitarism</subject><subject>Hypopituitarism - physiopathology</subject><subject>Hypothalamus</subject><subject>Interviews</subject><subject>Male</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Pituitary</subject><subject>Psychometrics</subject><subject>Qualitative research</subject><subject>Quality assessment</subject><subject>Quality of Life</subject><subject>Quantitative psychology</subject><subject>Questionnaires</subject><subject>Reliability analysis</subject><subject>Reproducibility of Results</subject><subject>Social and Behavioral Sciences</subject><subject>Surveys</subject><subject>Surveys and Questionnaires - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishii, Hitoshi</au><au>Shimatsu, Akira</au><au>Okimura, Yasuhiko</au><au>Tanaka, Toshiaki</au><au>Hizuka, Naomi</au><au>Kaji, Hidesuke</au><au>Hanew, Kunihiko</au><au>Oki, Yutaka</au><au>Yamashiro, Sayuri</au><au>Takano, Koji</au><au>Chihara, Kazuo</au><au>Heaton, Robert K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and validation of a new questionnaire assessing quality of life in adults with hypopituitarism: Adult Hypopituitarism Questionnaire (AHQ)</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-09-11</date><risdate>2012</risdate><volume>7</volume><issue>9</issue><spage>e44304</spage><epage>e44304</epage><pages>e44304-e44304</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To develop and validate the Adult Hypopituitarism Questionnaire (AHQ) as a disease-specific, self-administered questionnaire for evaluation of quality of life (QOL) in adult patients with hypopituitarism.
We developed and validated this new questionnaire, using a standardized procedure which included item development, pilot-testing and psychometric validation. Of the patients who participated in psychometric validation, those whose clinical conditions were judged to be stable were asked to answer the survey questionnaire twice, in order to assess test-retest reliability.
Content validity of the initial questionnaire was evaluated via two pilot tests. After these tests, we made minor revisions and finalized the initial version of the questionnaire. The questionnaire was constructed with two domains, one psycho-social and the other physical. For psychometric assessment, analyses were performed on the responses of 192 adult patients with various types of hypopituitarism. The intraclass correlations of the respective domains were 0.91 and 0.95, and the Cronbach's alpha coefficients were 0.96 and 0.95, indicating adequate test-retest reliability and internal consistency for each domain. For known-group validity, patients with hypopituitarism due to hypothalamic disorder showed significantly lower scores in 11 out of 13 sub-domains compared to those who had hypopituitarism due to pituitary disorder. Regarding construct validity, the domain structure was found to be almost the same as that initially hypothesized. Exploratory factor analysis (n = 228) demonstrated that each domain consisted of six and seven sub-domains.
The AHQ showed good reliability and validity for evaluating QOL in adult patients with hypopituitarism.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22984490</pmid><doi>10.1371/journal.pone.0044304</doi><tpages>e44304</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Adults Aged Aged, 80 and over Analysis Cognition Cohort Studies Diabetes Endocrinology Factor analysis Factor Analysis, Statistical Female Growth hormones Hospitals Humans Hypopituitarism Hypopituitarism - physiopathology Hypothalamus Interviews Male Medicine Metabolism Middle Aged Patients Pituitary Psychometrics Qualitative research Quality assessment Quality of Life Quantitative psychology Questionnaires Reliability analysis Reproducibility of Results Social and Behavioral Sciences Surveys Surveys and Questionnaires - standards Validity Young Adult |
| title | Development and validation of a new questionnaire assessing quality of life in adults with hypopituitarism: Adult Hypopituitarism Questionnaire (AHQ) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T21%3A47%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20and%20validation%20of%20a%20new%20questionnaire%20assessing%20quality%20of%20life%20in%20adults%20with%20hypopituitarism:%20Adult%20Hypopituitarism%20Questionnaire%20(AHQ)&rft.jtitle=PloS%20one&rft.au=Ishii,%20Hitoshi&rft.date=2012-09-11&rft.volume=7&rft.issue=9&rft.spage=e44304&rft.epage=e44304&rft.pages=e44304-e44304&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0044304&rft_dat=%3Cgale_plos_%3EA543313496%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1326545271&rft_id=info:pmid/22984490&rft_galeid=A543313496&rft_doaj_id=oai_doaj_org_article_8ecb6778c360402996305a050e70d408&rfr_iscdi=true |