Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma
MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C vir...
Gespeichert in:
| Veröffentlicht in: | PloS one 2012-09, Vol.7 (9), p.e44743 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 9 |
| container_start_page | e44743 |
| container_title | PloS one |
| container_volume | 7 |
| creator | Kumar, Vinod Yi Lo, Paulisally Hau Sawai, Hiromi Kato, Naoya Takahashi, Atsushi Deng, Zhenzhong Urabe, Yuji Mbarek, Hamdi Tokunaga, Katsushi Tanaka, Yasuhito Sugiyama, Masaya Mizokami, Masashi Muroyama, Ryosuke Tateishi, Ryosuke Omata, Masao Koike, Kazuhiko Tanikawa, Chizu Kamatani, Naoyuki Kubo, Michiaki Nakamura, Yusuke Matsuda, Koichi |
| description | MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA). In this study, we focused on the possible involvement of MICA in liver carcinogenesis related to hepatitis B virus (HBV) infection and examined correlation between the MICA polymorphism and the serum sMICA levels in HBV-induced HCC patients. The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). We also found a significant elevation of sMICA in HBV-induced HCC cases. Moreover, a G allele of SNP rs2596542 was significantly associated with increased sMICA levels (P = 0.009). Interestingly, HCC patients with the high serum level of sMICA (>5 pg/ml) exhibited poorer prognosis than those with the low serum level of sMICA (≤5 pg/ml) (P = 0.008). Thus, our results highlight the importance of MICA genetic variations and the significance of sMICA as a predictive biomarker for HBV-induced HCC. |
| doi_str_mv | 10.1371/journal.pone.0044743 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1326545118</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A543318620</galeid><doaj_id>oai_doaj_org_article_690e6146966640afa8ca2123be146d1f</doaj_id><sourcerecordid>A543318620</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-825a1d67f6f9c21193bd4748ea49c572768aacffd6115e3c8715a2e897645d843</originalsourceid><addsrcrecordid>eNqNkl2L1DAUhoso7jr6D0QLguBFx3w1TW-EdVF3YGXB1b0NZ9JkJmOmqUm76L83dbrLFBQkFwknz3lzzsmbZc8xWmJa4bc7P4QW3LLzrV4ixFjF6IPsFNeUFJwg-vDofJI9iXGHUEkF54-zE0IRYVVZnWbu2rth7XT-eXV-lkPb5HA43kKw0Fvf5hDzzsdoR6oLftP62FuVr63fQ_iuQ8yND_nF-5vCts2gdJNvdQe9V9q5wUHIFQRl20Q_zR4ZcFE_m_ZF9u3jh6_nF8Xl1af05mWhqlL0hSAl4IZXhptaEZy6WDepO6GB1aqsSMUFgDKm4RiXmipR4RKIFnXFWdkIRhfZy4Nu53yU06CixJTwkpUYi0SsDkTjYSe7YFMrv6QHK_8EfNhICKlLpyWvkeaY8ZpzzhAYEAoIJnStU7DBJmm9m14b1nvdKN32AdxMdH7T2q3c-FtJGaOoHst9NQkE_2PQsf9HyRO1gVSVbY1PYmpvo5JnJaMUi_GnF9nyL1Rajd5blaxibIrPEt7MEhLT65_9BoYY5er6y_-zVzdz9vURu9Xg-m1MXhstFecgO4AqJJcFbe4nh5EcnX43DTk6XU5OT2kvjqd-n3RnbfobKCH3qQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1326545118</pqid></control><display><type>article</type><title>Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Kumar, Vinod ; Yi Lo, Paulisally Hau ; Sawai, Hiromi ; Kato, Naoya ; Takahashi, Atsushi ; Deng, Zhenzhong ; Urabe, Yuji ; Mbarek, Hamdi ; Tokunaga, Katsushi ; Tanaka, Yasuhito ; Sugiyama, Masaya ; Mizokami, Masashi ; Muroyama, Ryosuke ; Tateishi, Ryosuke ; Omata, Masao ; Koike, Kazuhiko ; Tanikawa, Chizu ; Kamatani, Naoyuki ; Kubo, Michiaki ; Nakamura, Yusuke ; Matsuda, Koichi</creator><creatorcontrib>Kumar, Vinod ; Yi Lo, Paulisally Hau ; Sawai, Hiromi ; Kato, Naoya ; Takahashi, Atsushi ; Deng, Zhenzhong ; Urabe, Yuji ; Mbarek, Hamdi ; Tokunaga, Katsushi ; Tanaka, Yasuhito ; Sugiyama, Masaya ; Mizokami, Masashi ; Muroyama, Ryosuke ; Tateishi, Ryosuke ; Omata, Masao ; Koike, Kazuhiko ; Tanikawa, Chizu ; Kamatani, Naoyuki ; Kubo, Michiaki ; Nakamura, Yusuke ; Matsuda, Koichi</creatorcontrib><description>MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA). In this study, we focused on the possible involvement of MICA in liver carcinogenesis related to hepatitis B virus (HBV) infection and examined correlation between the MICA polymorphism and the serum sMICA levels in HBV-induced HCC patients. The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). We also found a significant elevation of sMICA in HBV-induced HCC cases. Moreover, a G allele of SNP rs2596542 was significantly associated with increased sMICA levels (P = 0.009). Interestingly, HCC patients with the high serum level of sMICA (>5 pg/ml) exhibited poorer prognosis than those with the low serum level of sMICA (≤5 pg/ml) (P = 0.008). Thus, our results highlight the importance of MICA genetic variations and the significance of sMICA as a predictive biomarker for HBV-induced HCC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0044743</identifier><identifier>PMID: 23024757</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Alleles ; Analysis ; Association analysis ; Bioindicators ; Biology ; Biomarkers ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - genetics ; Carcinogenesis ; Carcinogens ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - virology ; Deoxyribonucleic acid ; Disease control ; DNA ; Female ; Gastroenterology ; Gene polymorphism ; Genetic analysis ; Genetic aspects ; Genetic diversity ; Genetic testing ; Genomes ; Health aspects ; Hepatitis ; Hepatitis B ; Hepatitis B virus ; Hepatitis C ; Hepatitis C virus ; Hepatocellular carcinoma ; Histocompatibility Antigens Class I - blood ; Histocompatibility Antigens Class I - genetics ; Humans ; Immunology ; Infection ; Infections ; Laboratories ; Ligands ; Liver ; Liver cancer ; Liver Neoplasms - blood ; Liver Neoplasms - genetics ; Liver Neoplasms - mortality ; Liver Neoplasms - virology ; Lymphocytes ; Major histocompatibility complex ; Male ; Medical prognosis ; Medicine ; MICA protein ; Middle Aged ; Minisatellite Repeats ; Neovascularization, Pathologic - blood ; Neovascularization, Pathologic - genetics ; Pathogenesis ; Patients ; Polymorphism ; Polymorphism, Single Nucleotide ; Prognosis ; Science ; Serum levels ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Viral infections ; Viruses</subject><ispartof>PloS one, 2012-09, Vol.7 (9), p.e44743</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Kumar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Kumar et al 2012 Kumar et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-825a1d67f6f9c21193bd4748ea49c572768aacffd6115e3c8715a2e897645d843</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443094/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443094/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23024757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Vinod</creatorcontrib><creatorcontrib>Yi Lo, Paulisally Hau</creatorcontrib><creatorcontrib>Sawai, Hiromi</creatorcontrib><creatorcontrib>Kato, Naoya</creatorcontrib><creatorcontrib>Takahashi, Atsushi</creatorcontrib><creatorcontrib>Deng, Zhenzhong</creatorcontrib><creatorcontrib>Urabe, Yuji</creatorcontrib><creatorcontrib>Mbarek, Hamdi</creatorcontrib><creatorcontrib>Tokunaga, Katsushi</creatorcontrib><creatorcontrib>Tanaka, Yasuhito</creatorcontrib><creatorcontrib>Sugiyama, Masaya</creatorcontrib><creatorcontrib>Mizokami, Masashi</creatorcontrib><creatorcontrib>Muroyama, Ryosuke</creatorcontrib><creatorcontrib>Tateishi, Ryosuke</creatorcontrib><creatorcontrib>Omata, Masao</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><creatorcontrib>Tanikawa, Chizu</creatorcontrib><creatorcontrib>Kamatani, Naoyuki</creatorcontrib><creatorcontrib>Kubo, Michiaki</creatorcontrib><creatorcontrib>Nakamura, Yusuke</creatorcontrib><creatorcontrib>Matsuda, Koichi</creatorcontrib><title>Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA). In this study, we focused on the possible involvement of MICA in liver carcinogenesis related to hepatitis B virus (HBV) infection and examined correlation between the MICA polymorphism and the serum sMICA levels in HBV-induced HCC patients. The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). We also found a significant elevation of sMICA in HBV-induced HCC cases. Moreover, a G allele of SNP rs2596542 was significantly associated with increased sMICA levels (P = 0.009). Interestingly, HCC patients with the high serum level of sMICA (>5 pg/ml) exhibited poorer prognosis than those with the low serum level of sMICA (≤5 pg/ml) (P = 0.008). Thus, our results highlight the importance of MICA genetic variations and the significance of sMICA as a predictive biomarker for HBV-induced HCC.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Association analysis</subject><subject>Bioindicators</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Deoxyribonucleic acid</subject><subject>Disease control</subject><subject>DNA</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gene polymorphism</subject><subject>Genetic analysis</subject><subject>Genetic aspects</subject><subject>Genetic diversity</subject><subject>Genetic testing</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B virus</subject><subject>Hepatitis C</subject><subject>Hepatitis C virus</subject><subject>Hepatocellular carcinoma</subject><subject>Histocompatibility Antigens Class I - blood</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infection</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Ligands</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - virology</subject><subject>Lymphocytes</subject><subject>Major histocompatibility complex</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>MICA protein</subject><subject>Middle Aged</subject><subject>Minisatellite Repeats</subject><subject>Neovascularization, Pathologic - blood</subject><subject>Neovascularization, Pathologic - genetics</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prognosis</subject><subject>Science</subject><subject>Serum levels</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7jr6D0QLguBFx3w1TW-EdVF3YGXB1b0NZ9JkJmOmqUm76L83dbrLFBQkFwknz3lzzsmbZc8xWmJa4bc7P4QW3LLzrV4ixFjF6IPsFNeUFJwg-vDofJI9iXGHUEkF54-zE0IRYVVZnWbu2rth7XT-eXV-lkPb5HA43kKw0Fvf5hDzzsdoR6oLftP62FuVr63fQ_iuQ8yND_nF-5vCts2gdJNvdQe9V9q5wUHIFQRl20Q_zR4ZcFE_m_ZF9u3jh6_nF8Xl1af05mWhqlL0hSAl4IZXhptaEZy6WDepO6GB1aqsSMUFgDKm4RiXmipR4RKIFnXFWdkIRhfZy4Nu53yU06CixJTwkpUYi0SsDkTjYSe7YFMrv6QHK_8EfNhICKlLpyWvkeaY8ZpzzhAYEAoIJnStU7DBJmm9m14b1nvdKN32AdxMdH7T2q3c-FtJGaOoHst9NQkE_2PQsf9HyRO1gVSVbY1PYmpvo5JnJaMUi_GnF9nyL1Rajd5blaxibIrPEt7MEhLT65_9BoYY5er6y_-zVzdz9vURu9Xg-m1MXhstFecgO4AqJJcFbe4nh5EcnX43DTk6XU5OT2kvjqd-n3RnbfobKCH3qQ</recordid><startdate>20120914</startdate><enddate>20120914</enddate><creator>Kumar, Vinod</creator><creator>Yi Lo, Paulisally Hau</creator><creator>Sawai, Hiromi</creator><creator>Kato, Naoya</creator><creator>Takahashi, Atsushi</creator><creator>Deng, Zhenzhong</creator><creator>Urabe, Yuji</creator><creator>Mbarek, Hamdi</creator><creator>Tokunaga, Katsushi</creator><creator>Tanaka, Yasuhito</creator><creator>Sugiyama, Masaya</creator><creator>Mizokami, Masashi</creator><creator>Muroyama, Ryosuke</creator><creator>Tateishi, Ryosuke</creator><creator>Omata, Masao</creator><creator>Koike, Kazuhiko</creator><creator>Tanikawa, Chizu</creator><creator>Kamatani, Naoyuki</creator><creator>Kubo, Michiaki</creator><creator>Nakamura, Yusuke</creator><creator>Matsuda, Koichi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120914</creationdate><title>Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma</title><author>Kumar, Vinod ; Yi Lo, Paulisally Hau ; Sawai, Hiromi ; Kato, Naoya ; Takahashi, Atsushi ; Deng, Zhenzhong ; Urabe, Yuji ; Mbarek, Hamdi ; Tokunaga, Katsushi ; Tanaka, Yasuhito ; Sugiyama, Masaya ; Mizokami, Masashi ; Muroyama, Ryosuke ; Tateishi, Ryosuke ; Omata, Masao ; Koike, Kazuhiko ; Tanikawa, Chizu ; Kamatani, Naoyuki ; Kubo, Michiaki ; Nakamura, Yusuke ; Matsuda, Koichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-825a1d67f6f9c21193bd4748ea49c572768aacffd6115e3c8715a2e897645d843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Analysis</topic><topic>Association analysis</topic><topic>Bioindicators</topic><topic>Biology</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Deoxyribonucleic acid</topic><topic>Disease control</topic><topic>DNA</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gene polymorphism</topic><topic>Genetic analysis</topic><topic>Genetic aspects</topic><topic>Genetic diversity</topic><topic>Genetic testing</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B virus</topic><topic>Hepatitis C</topic><topic>Hepatitis C virus</topic><topic>Hepatocellular carcinoma</topic><topic>Histocompatibility Antigens Class I - blood</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infection</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Ligands</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - virology</topic><topic>Lymphocytes</topic><topic>Major histocompatibility complex</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>MICA protein</topic><topic>Middle Aged</topic><topic>Minisatellite Repeats</topic><topic>Neovascularization, Pathologic - blood</topic><topic>Neovascularization, Pathologic - genetics</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prognosis</topic><topic>Science</topic><topic>Serum levels</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Viral infections</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Vinod</creatorcontrib><creatorcontrib>Yi Lo, Paulisally Hau</creatorcontrib><creatorcontrib>Sawai, Hiromi</creatorcontrib><creatorcontrib>Kato, Naoya</creatorcontrib><creatorcontrib>Takahashi, Atsushi</creatorcontrib><creatorcontrib>Deng, Zhenzhong</creatorcontrib><creatorcontrib>Urabe, Yuji</creatorcontrib><creatorcontrib>Mbarek, Hamdi</creatorcontrib><creatorcontrib>Tokunaga, Katsushi</creatorcontrib><creatorcontrib>Tanaka, Yasuhito</creatorcontrib><creatorcontrib>Sugiyama, Masaya</creatorcontrib><creatorcontrib>Mizokami, Masashi</creatorcontrib><creatorcontrib>Muroyama, Ryosuke</creatorcontrib><creatorcontrib>Tateishi, Ryosuke</creatorcontrib><creatorcontrib>Omata, Masao</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><creatorcontrib>Tanikawa, Chizu</creatorcontrib><creatorcontrib>Kamatani, Naoyuki</creatorcontrib><creatorcontrib>Kubo, Michiaki</creatorcontrib><creatorcontrib>Nakamura, Yusuke</creatorcontrib><creatorcontrib>Matsuda, Koichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Vinod</au><au>Yi Lo, Paulisally Hau</au><au>Sawai, Hiromi</au><au>Kato, Naoya</au><au>Takahashi, Atsushi</au><au>Deng, Zhenzhong</au><au>Urabe, Yuji</au><au>Mbarek, Hamdi</au><au>Tokunaga, Katsushi</au><au>Tanaka, Yasuhito</au><au>Sugiyama, Masaya</au><au>Mizokami, Masashi</au><au>Muroyama, Ryosuke</au><au>Tateishi, Ryosuke</au><au>Omata, Masao</au><au>Koike, Kazuhiko</au><au>Tanikawa, Chizu</au><au>Kamatani, Naoyuki</au><au>Kubo, Michiaki</au><au>Nakamura, Yusuke</au><au>Matsuda, Koichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-09-14</date><risdate>2012</risdate><volume>7</volume><issue>9</issue><spage>e44743</spage><pages>e44743-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>MHC class I polypeptide-related chain A (MICA) molecule is induced in response to viral infection and various types of stress. We recently reported that a single nucleotide polymorphism (SNP) rs2596542 located in the MICA promoter region was significantly associated with the risk for hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC) and also with serum levels of soluble MICA (sMICA). In this study, we focused on the possible involvement of MICA in liver carcinogenesis related to hepatitis B virus (HBV) infection and examined correlation between the MICA polymorphism and the serum sMICA levels in HBV-induced HCC patients. The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). We also found a significant elevation of sMICA in HBV-induced HCC cases. Moreover, a G allele of SNP rs2596542 was significantly associated with increased sMICA levels (P = 0.009). Interestingly, HCC patients with the high serum level of sMICA (>5 pg/ml) exhibited poorer prognosis than those with the low serum level of sMICA (≤5 pg/ml) (P = 0.008). Thus, our results highlight the importance of MICA genetic variations and the significance of sMICA as a predictive biomarker for HBV-induced HCC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23024757</pmid><doi>10.1371/journal.pone.0044743</doi><tpages>e44743</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-09, Vol.7 (9), p.e44743 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1326545118 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Aged Alleles Analysis Association analysis Bioindicators Biology Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Carcinogenesis Carcinogens Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - virology Deoxyribonucleic acid Disease control DNA Female Gastroenterology Gene polymorphism Genetic analysis Genetic aspects Genetic diversity Genetic testing Genomes Health aspects Hepatitis Hepatitis B Hepatitis B virus Hepatitis C Hepatitis C virus Hepatocellular carcinoma Histocompatibility Antigens Class I - blood Histocompatibility Antigens Class I - genetics Humans Immunology Infection Infections Laboratories Ligands Liver Liver cancer Liver Neoplasms - blood Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - virology Lymphocytes Major histocompatibility complex Male Medical prognosis Medicine MICA protein Middle Aged Minisatellite Repeats Neovascularization, Pathologic - blood Neovascularization, Pathologic - genetics Pathogenesis Patients Polymorphism Polymorphism, Single Nucleotide Prognosis Science Serum levels Single nucleotide polymorphisms Single-nucleotide polymorphism Viral infections Viruses |
| title | Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T14%3A47%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Soluble%20MICA%20and%20a%20MICA%20variation%20as%20possible%20prognostic%20biomarkers%20for%20HBV-induced%20hepatocellular%20carcinoma&rft.jtitle=PloS%20one&rft.au=Kumar,%20Vinod&rft.date=2012-09-14&rft.volume=7&rft.issue=9&rft.spage=e44743&rft.pages=e44743-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0044743&rft_dat=%3Cgale_plos_%3EA543318620%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1326545118&rft_id=info:pmid/23024757&rft_galeid=A543318620&rft_doaj_id=oai_doaj_org_article_690e6146966640afa8ca2123be146d1f&rfr_iscdi=true |