Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent

Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages. Hepcidin is synthesized mainly in the liver, where hepcidin is regulated by iron loading, inflammation and hypoxia. Recentl...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e44622-e44622
Hauptverfasser:	Wu, Xinggang, Yung, Lai-Ming, Cheng, Wai-Hang, Yu, Paul B, Babitt, Jodie L, Lin, Herbert Y, Xia, Yin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Animals Antimicrobial Cationic Peptides Autocrine signalling Bacterial diseases Bacterial infections Biology Blotting, Western Bone morphogenetic protein 4 Bone Morphogenetic Protein 4 - pharmacology Bone morphogenetic protein 6 Bone Morphogenetic Protein 6 - pharmacology Bone morphogenetic proteins Bone Morphogenetic Proteins - pharmacology Cell Line Cell lines Cells, Cultured Cytokines Diet Health aspects Hepatocytes Hepcidin Hepcidins Homeostasis Hospitals Hypoxia Id1 protein Immunology Inflammation Inhibitor of Differentiation Protein 1 - metabolism Iron Kinases Ligands Lipopolysaccharides Lipopolysaccharides - pharmacology Liver Loading Macrophages Macrophages - drug effects Macrophages - metabolism Mechanical loading Medical schools Medicine Mice Mitogens Nephrology NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB protein Paracrine signalling Peritoneum Phosphorylation Phosphorylation - drug effects Proteins Rodents Smad protein Smad1 Protein - metabolism Smad5 Protein - metabolism Smad8 Protein - metabolism Sulfoxides - pharmacology Tetrazoles - pharmacology Womens health
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