Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria

Secondary bacterial pneumonias are a frequent complication of influenza and other respiratory viral infections, but the mechanisms underlying viral-induced susceptibility to bacterial infections are poorly understood. In particular, it is unclear whether the host's response against the viral in...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e41879
Hauptverfasser:	Tian, Xiaoli, Xu, Feng, Lung, Wing Yi, Meyerson, Cherise, Ghaffari, Amir Ali, Cheng, Genhong, Deng, Jane C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoquinolines - pharmacology Animals Antibacterial agents Antibodies - pharmacology Antigens, Viral - administration & dosage Antigens, Viral - immunology Bacteria Bacterial infections Biology Disease Susceptibility Double-stranded RNA Drug resistance Gene Expression Regulation - drug effects Gram-positive bacteria Health aspects Imidazoles - pharmacology Imiquimod Immune clearance Immune system Impairment Indexing in process Infections Influenza Interferon Interferon Inducers - pharmacology Interferon Type I - genetics Interferon Type I - immunology Ligands Lungs Medicine Membrane Proteins - genetics Membrane Proteins - immunology Methicillin Methicillin-Resistant Staphylococcus aureus - immunology Mice Nerve Tissue Proteins - genetics Nerve Tissue Proteins - immunology Nucleic acids Pandemics Pathogens Pneumococcal Infections - genetics Pneumococcal Infections - immunology Pneumococcal Infections - microbiology Pneumococcal Infections - mortality Pneumonia Pneumonia, Bacterial - genetics Pneumonia, Bacterial - immunology Pneumonia, Bacterial - microbiology Pneumonia, Bacterial - mortality Poly I-C - administration & dosage Poly I-C - immunology Polyinosinic:polycytidylic acid Proteins Receptor, Interferon alpha-beta - genetics Receptor, Interferon alpha-beta - immunology Retinoic acid Signal Transduction - drug effects Signaling Staphylococcal Infections - genetics Staphylococcal Infections - immunology Staphylococcal Infections - microbiology Staphylococcal Infections - mortality Staphylococcus aureus Staphylococcus aureus infections Streptococcus infections Streptococcus pneumoniae - immunology Survival Rate Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - immunology Toll-like receptors Trachea Viral infections Viruses
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