LAPTM4B allele 2 is associated with breast cancer susceptibility and prognosis

Lysosome-associated protein transmembrane 4 beta (LAPTM4B) has two alleles named LAPTM4B*1 and LAPTM4B*2. Allele *1 contains only one copy of a 19-bp sequence at the 5'UTR in the first exon, whereas this sequence of allele*2 is duplicated and arrayed as a tandem repeat. Previous studies reveale...

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Veröffentlicht in:	PloS one 2012-09, Vol.7 (9), p.e44916-e44916
Hauptverfasser:	Li, Xiaoyan, Kong, Xiangnan, Chen, Xi, Zhang, Ning, Jiang, Liyu, Ma, Tingting, Yang, Qifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Analysis Biomarkers, Tumor - metabolism Biotechnology Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - genetics Cancer Cancer research Correlation Correlation analysis Deoxyribonucleic acid Development and progression Disease Progression Disease susceptibility DNA Female Gallbladder Genetic aspects Genetic Predisposition to Disease Genotype Genotyping Health risks Humans Liver cancer Lymph nodes Medical diagnosis Medical prognosis Medicine Membrane Proteins - genetics Metastases Metastasis Middle Aged Models, Genetic Nucleotide sequence Oncogene Proteins - genetics Ovarian cancer Polymorphism Polymorphism, Genetic Prognosis Proteins Reverse Transcriptase Polymerase Chain Reaction - methods Risk Factors Statistical analysis Surgery Tissues Tumor cell lines Tumors
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