MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells

Oxidative injury to retinal pigment epithelium (RPE) and retinal photoreceptors has been linked to a number of retinal diseases, including age-related macular degeneration (AMD). Reactive oxygen species (ROS)-mediated gene expression has been extensively studied at transcriptional levels. Also, the...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e42542
Hauptverfasser:	Haque, Rashidul, Chun, Eugene, Howell, Jennifer C, Sengupta, Trisha, Chen, Dan, Kim, Hana
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Age Alzheimer's disease Antioxidants Antisense RNA Base Sequence Biology Catalase Catalase - antagonists & inhibitors Catalase - genetics Catalase - metabolism Cell Line Cell Survival - drug effects Computational Biology Cytoprotection - drug effects Deoxyribonucleic acid Diabetes Diabetic retinopathy DNA Epithelium Gene expression Gene Expression Regulation, Enzymologic - drug effects Gene regulation Genes Genetic aspects Humans Hydrogen Hydrogen peroxide Hydrogen Peroxide - pharmacology Macaca mulatta Macular degeneration Medicine MicroRNA MicroRNAs MicroRNAs - metabolism miRNA Mitochondria Molecular Sequence Data Oligonucleotides - pharmacology Oxidative stress Oxidative Stress - drug effects Oxidizing agents Oxygen Pan troglodytes Photoreceptors Physiological aspects Post-transcription Protein Binding - drug effects Protein Carbonylation - drug effects Proteins Reactive oxygen species Reproducibility of Results Retina Retinal pigment epithelium Retinal Pigment Epithelium - cytology Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - enzymology Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Sublethal dosage Transcription (Genetics)
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