A resealed-cell system for analyzing pathogenic intracellular events: perturbation of endocytic pathways under diabetic conditions

Cell-based assay systems that can serve as cellular models of aberrant function in pathogenic organs would be novel and useful tools for screening drugs and clarifying the molecular mechanisms of various diseases. We constructed model cells that replicated the conditions in diabetic hepatocytes by u...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e44127
Hauptverfasser:	Kano, Fumi, Nakatsu, Daiki, Noguchi, Yoshiyuki, Yamamoto, Akitsugu, Murata, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Animal models Animals Bacterial Proteins - pharmacology Biology Calcium Calcium Chloride - pharmacology Cell cycle Cell Membrane Permeability - drug effects Cholera Toxin - metabolism Cytosol Dextrans - metabolism Diabetes Diabetes mellitus Diabetes Mellitus - metabolism Diabetes Mellitus - pathology Disease DNA methylation Drug screening Drugs Endocytosis - drug effects Endosomes Endosomes - drug effects Endosomes - metabolism Endosomes - ultrastructure Epidermal growth factor Fluoresceins - metabolism Golgi apparatus Golgi Apparatus - drug effects Golgi Apparatus - metabolism Golgi Apparatus - ultrastructure HeLa Cells Hepatocytes Humans Intracellular Space - drug effects Intracellular Space - metabolism Kinases Life sciences Liver Liver - drug effects Liver - metabolism Liver - pathology Liver cells Lymphocytes Lysosomes MAP kinase Mice Models, Biological Molecular modelling Molecular Weight Organs p38 Mitogen-Activated Protein Kinases - metabolism Pathways Perturbation methods Phosphates Phosphatidylinositol Phosphates - metabolism Phosphorylation Physiological aspects Plasma Protein Transport - drug effects Proteins Proteolysis - drug effects Receptor, Epidermal Growth Factor - metabolism Rodents Signal transduction Streptolysins - pharmacology Therapeutic applications Toxins Transferrin - metabolism
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