Tungstate reduces the expression of gluconeogenic enzymes in STZ rats

Oral administration of sodium tungstate has shown hyperglycemia-reducing activity in several animal models of diabetes. We present new insights into the mechanism of action of tungstate. We studied protein expression and phosphorylation in the liver of STZ rats, a type I diabetes model, treated with...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e42305-e42305
Hauptverfasser:	Nocito, Laura, Zafra, Delia, Calbó, Joaquim, Domínguez, Jorge, Guinovart, Joan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral AKT protein Animal models Animals Biochemistry Biology c-Fos protein c-Jun protein Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Drinking behavior Drinking water Enzymes Extracellular signal-regulated kinase Gene expression Gluconeogenesis - drug effects Glucose Glucose - metabolism Glycogen Synthase - metabolism Hepatocytes Hepatocytes - drug effects Hyperglycemia Insulin Kinases Laboratory animals Liver Liver - drug effects Liver - metabolism Male Medicine Metabolism Metabolites Molecular biology Musculoskeletal system Oral administration Phosphorylation Physiological aspects Proteins Rats Rats, Wistar Rodents Signal transduction Signaling Sodium Sodium tungstate Streptozocin - pharmacology Transcription factors Tungsten compounds Tungsten Compounds - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!