Scavenger receptors in human airway epithelial cells: role in response to double-stranded RNA

Scavenger receptors and Toll-like receptors (TLRs) cooperate in response to danger signals to adjust the host immune response. The TLR3 agonist double stranded (ds)RNA is an efficient activator of innate signalling in bronchial epithelial cells. In this study, we aimed at defining the role played by...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e41952
Hauptverfasser:	Dieudonné, Audrey, Torres, David, Blanchard, Simon, Taront, Solenne, Jeannin, Pascale, Delneste, Yves, Pichavant, Muriel, Trottein, François, Gosset, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Albumin Alveoli Animals B cells Biology Bronchi - cytology Bronchoalveolar Lavage Fluid - cytology Bronchus Cell activation Cell Membrane - drug effects Cell Membrane - metabolism Chemokines CXCL16 protein Cytokines Cytokines - biosynthesis Dendritic cells Double-stranded RNA Endocytosis - drug effects Epithelial cells Epithelial Cells - cytology Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - metabolism Gene Silencing - drug effects Hazards Humans Immune response Immune system Immunology Induced infiltration Infiltration Inflammation Interferon Kinases Life Sciences Ligands Liquid oxygen LOX-1 protein Lungs Lymph nodes Medicine Metastases Mice Mice, Inbred C57BL Ovalbumin Ovalbumin - administration & dosage Poly I-C - pharmacology Proteins Receptors Receptors, Scavenger - genetics Receptors, Scavenger - metabolism Respiratory tract Ribonucleic acid RNA RNA, Double-Stranded - pharmacology RNA, Messenger - genetics RNA, Messenger - metabolism RNA-mediated interference Scavenger receptors Signal Transduction - drug effects Signal Transduction - genetics Signaling Streptococcus infections Supplements TLR3 protein Toll-like receptors Tumor necrosis factor-TNF Tumor necrosis factor-α Virus diseases
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