Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes

The study aimed to identify endogenous lipid mediators of metabolic and inflammatory responses of human keratinocytes to solar UV irradiation. Physiologically relevant doses of solar simulated UVA+UVB were applied to human skin surface lipids (SSL) or to primary cultures of normal human epidermal ke...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e44472
Hauptverfasser:	Kostyuk, Vladimir, Potapovich, Alla, Stancato, Andrea, De Luca, Chiara, Lulli, Daniela, Pastore, Saveria, Korkina, Liudmila
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aldehydes - pharmacology Arachidonic acid Aromatic compounds Aryl Hydrocarbon Hydroxylases - metabolism Biology Carbazole Carbazoles - pharmacology Causes of Cholesterol Cyclooxygenase 2 - metabolism Cyclooxygenase-2 CYP1B1 gene Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1B1 Cytochrome P450 Cytokines - genetics Cytokines - metabolism Dose-Response Relationship, Radiation Epidermal growth factor receptors Epidermis - pathology ErbB Receptors - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - radiation effects Genetic aspects Human behavior Humans Inflammation Inflammation - pathology Interleukin 6 Irradiation Isoenzymes - metabolism Keratinocytes Keratinocytes - enzymology Keratinocytes - metabolism Keratinocytes - pathology Keratinocytes - radiation effects Kinases Lipids Machinery Machinery and equipment Male Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Oxidation Oxidation-Reduction - drug effects Oxidation-Reduction - radiation effects Photooxidation Physics Physiological aspects Receptors, Aryl Hydrocarbon - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Signal Transduction - radiation effects Skin Skin - radiation effects Squalene Squalene - pharmacology Surface Properties - drug effects Surface Properties - radiation effects Time Factors Tocopherol Tryptophan U.V. radiation Ultraviolet radiation Ultraviolet Rays
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