Protective efficacy of Newcastle disease virus expressing soluble trimeric hemagglutinin against highly pathogenic H5N1 influenza in chickens and mice

Highly pathogenic avian influenza virus (HPAIV) causes a highly contagious often fatal disease in poultry, resulting in significant economic losses in the poultry industry. HPAIV H5N1 also poses a major public health threat as it can be transmitted directly from infected poultry to humans. One effec...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e44447-e44447
Hauptverfasser:	Cornelissen, Lisette A H M, de Leeuw, Olav S, Tacken, Mirriam G, Klos, Heleen C, de Vries, Robert P, de Boer-Luijtze, Els A, van Zoelen-Bos, Diana J, Rigter, Alan, Rottier, Peter J M, Moormann, Rob J M, de Haan, Cornelis A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal vaccines Animals Antibody Formation - immunology Antibody response Antigens Avian flu avian influenza Biology Chickens Chickens - immunology Chickens - virology Economic impact Female fowlpox virus fusion protein Genomes Health risks Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinin Glycoproteins, Influenza Virus - isolation & purification Hemagglutinins Humans Immunity Immunization Immunoglobulins Immunology Infections Infectious diseases Influenza Influenza A Virus, H5N1 Subtype - immunology Influenza in Birds - blood Influenza in Birds - immunology Influenza in Birds - prevention & control Influenza in Birds - virology lethal challenge Mammals Medicine Membrane proteins Mice Mice, Inbred BALB C neutralizing antibodies Newcastle disease Newcastle disease virus - immunology Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Pandemics Pathogenicity Pathogens Poultry Protein Multimerization Proteins Public health recombinant Recombinants Recombination, Genetic - genetics Respiratory tract Solubility Treatment Outcome Tropism Vaccination vaccine vectors Vaccines Veterinary medicine Veterinary Science Virology virulence Virus Shedding - immunology Viruses Zoonoses
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