An antitubulin agent BCFMT inhibits proliferation of cancer cells and induces cell death by inhibiting microtubule dynamics

Using cell based screening assay, we identified a novel anti-tubulin agent (Z)-5-((5-(4-bromo-3-chlorophenyl)furan-2-yl)methylene)-2-thioxothiazolidin-4-one (BCFMT) that inhibited proliferation of human cervical carcinoma (HeLa) (IC(50), 7.2 ± 1.8 µM), human breast adenocarcinoma (MCF-7) (IC(50), 10...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e44311
Hauptverfasser:	Rai, Ankit, Surolia, Avadhesha, Panda, Dulal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animals Antineoplastic agents Apoptosis Bioengineering Biology BUBR1 protein Calcium-Binding Proteins - metabolism Cancer Cancer cells Cell culture Cell cycle Cell Cycle - drug effects Cell Cycle Proteins - metabolism Cell death Cell Death - drug effects Cell division Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cervical cancer Cervical carcinoma Cervix Chemotherapy Cisplatin Complications and side effects Cyclin B1 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Depolymerization Dissociation Dosage and administration Downstream effects Drug resistance Drug Screening Assays, Antitumor Genetic aspects Guanosine triphosphatases Guanosinetriphosphatase Humans Inhibition Kinetochores Kinetochores - drug effects Mad2 Proteins Mammary gland Medicine Metastases Metastasis Mice Microtubules Microtubules - drug effects Microtubules - metabolism Mitotic Index Multidrug resistance Neoplasms - pathology Ovarian cancer Ovarian carcinoma p53 Protein Pandas Physiological aspects Polymerization - drug effects Porphobilinogen - analogs & derivatives Porphobilinogen - metabolism Protein-Serine-Threonine Kinases - metabolism Proteins Repressor Proteins - metabolism Rhodanine - pharmacology Thiazolidines - chemistry Thiazolidines - pharmacology Thiones - chemistry Thiones - pharmacology Tubulin Tubulin - metabolism Tubulin Modulators - chemistry Tubulin Modulators - pharmacology Tumor Suppressor Protein p53 - metabolism Tumors Vinblastine Vinblastine - pharmacology
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