A novel five gene signature derived from stem-like side population cells predicts overall and recurrence-free survival in NSCLC

Gene expression profiling has been used to characterize prognosis in various cancers. Earlier studies had shown that side population cells isolated from Non-Small Cell Lung Cancer (NSCLC) cell lines exhibit cancer stem cell properties. In this study we apply a systems biology approach to gene expres...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e43589-e43589
Hauptverfasser:	Perumal, Deepak, Singh, Sandeep, Yoder, Sean J, Bloom, Gregory C, Chellappan, Srikumar P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Biology Biotechnology Cancer Cancer recurrence Cancer therapies Carcinoma, Non-Small-Cell Lung - pathology Care and treatment Cell Line, Tumor Cell survival Chromosomes Disease-Free Survival DNA microarrays Gene amplification Gene expression Genes Genetic aspects Genomics Humans Kinases Lung cancer Lung diseases Lung Neoplasms - pathology Medical prognosis Medical research Medicine Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Non-small cell lung cancer Non-small cell lung carcinoma Oligonucleotide Array Sequence Analysis Patients Population Principal Component Analysis Principal components analysis Prognosis Properties (attributes) Real-Time Polymerase Chain Reaction Risk factors Senescence Stem cells Studies Survival Transcriptome Translocation Tumor cell lines Tumors
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