Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners

Cathepsin S (catS), which is expressed in normal human keratinocytes and localized close to the dermal-epidermal junction (DEJ) degrades some of major basement membrane (BM) constituents. Among them, catS readily hydrolyzed in a time and dose dependent manner human nidogen-1 (nid-1) and nidogen-2, w...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e43494-e43494
Hauptverfasser:	Sage, Juliette, Leblanc-Noblesse, Emmanuelle, Nizard, Carine, Sasaki, Takako, Schnebert, Sylvianne, Perrier, Eric, Kurfurst, Robin, Brömme, Dieter, Lalmanach, Gilles, Lecaille, Fabien
Format:	Artikel
Sprache:	eng
Schlagworte:	Basement Membrane - metabolism Basement membranes Binding Biology Cathepsin S Cathepsins Cathepsins - chemistry Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism Cleavage Collagen Crosslinking Dermis - metabolism Epidermis - metabolism Extracellular matrix Genetic aspects Heparan sulfate Humans Hydrolysis Keratinocytes Keratinocytes - cytology Ligands Low density lipoprotein receptors Lysates Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Models, Genetic Morphogenesis Physiological aspects Pichia - metabolism Protein Binding Proteins Proteolysis Rheology - methods Skin Skin - pathology Spleen Surface Plasmon Resonance Viscoelasticity
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