Prenatal exposure to bereavement and type-2 diabetes: a Danish longitudinal population based study
The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the association between p...
Gespeichert in:
| Veröffentlicht in: | PloS one 2012-08, Vol.7 (8), p.e43508 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | e43508 |
| container_title | PloS one |
| container_volume | 7 |
| creator | Virk, Jasveer Li, Jiong Vestergaard, Mogens Obel, Carsten Kristensen, Jette Kolding Olsen, Jørn |
| description | The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the association between prenatal exposure to maternal bereavement during preconception and pregnancy and development of type-2 diabetes in the off-spring.
We utilized data from the Danish Civil Registration System to identify singleton births in Denmark born January 1(st) 1979 through December 31(st) 2008 (N = 1,878,246), and linked them to their parents, grandparents, and siblings. We categorized children as exposed to bereavement during prenatal life if their mothers lost an elder child, husband or parent during the period from one year before conception to the child's birth. We identified 45,302 children exposed to maternal bereavement; the remaining children were included in the unexposed cohort. The outcome of interest was diagnosis of type-2 diabetes. We estimated incidence rate ratios (IRRs) from birth using log-linear poisson regression models and used person-years as the offset variable. All models were adjusted for maternal residence, income, education, marital status, sibling order, calendar year, sex, and parents' history of diabetes at the time of pregnancy.
We found children exposed to bereavement during their prenatal life were more likely to have a type-2 diabetes diagnosis later in life (aIRR: 1.31, 1.01-1.69). These findings were most pronounced when bereavement was caused by death of an elder child (aIRR: 1.51, 0.94-2.44). Results also indicated the second trimester of pregnancy to be the most sensitive period of bereavement exposure (aIRR:2.08, 1.15-3.76).
Our data suggests that fetal exposure to maternal bereavement during preconception and the prenatal period may increase the risk for developing type-2 diabetes in childhood and young adulthood. |
| doi_str_mv | 10.1371/journal.pone.0043508 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1326450542</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A498244657</galeid><doaj_id>oai_doaj_org_article_6ef0c8c3f05e487eb65b25fb8f08b8ca</doaj_id><sourcerecordid>A498244657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-21dc69e96984b5ecf416b76d59c3b9dd72e5d2483758736e68152ee5309669d73</originalsourceid><addsrcrecordid>eNqNkl1rFDEUhgdRbK3-A9GAIHixayZfk_RCKPVroVDx6zZkJmd2s8xOxiRTuv_erDstu6AguUg4ec6bk5e3KJ6XeF7Sqny79mPoTTcffA9zjBnlWD4oTktFyUwQTB8enE-KJzGuMeZUCvG4OCFEcSKUPC3qLwF6k0yH4HbwcQyAkkc1BDA3sIE-IdNblLYDzAiyztSQIJ4jg96b3sUV6ny_dGm0Lo-CBj-MnUnO96g2ESyK-Wb7tHjUmi7Cs2k_K358_PD98vPs6vrT4vLiatYIRdKMlDYfQOWxWM2haVkp6kpYrhpaK2srAtwSJmnFZUUFCFlyAsApVkIoW9Gz4uVed-h81JM9UZeUCMYxZyQTiz1hvVnrIbiNCVvtjdN_Cj4stQnJNR1oAS1uZENbzIHJCmrBa8LbWrZY1rIxWevd9NpYb8A22apguiPR45verfTS32jKiGKqzAKvJoHgf40Q0z9GnqilyVO5vvVZrNm42OgLpiRhTPDd1-d_ofKysHFNDkjrcv2o4c1RQ2YS3KalGWPUi29f_5-9_nnMvj5gV2C6tIq-G3eZiMcg24NN8DEGaO-dK7He5fvODb3Lt57yndteHLp-33QXaPobNeT2CA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1326450542</pqid></control><display><type>article</type><title>Prenatal exposure to bereavement and type-2 diabetes: a Danish longitudinal population based study</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Virk, Jasveer ; Li, Jiong ; Vestergaard, Mogens ; Obel, Carsten ; Kristensen, Jette Kolding ; Olsen, Jørn</creator><creatorcontrib>Virk, Jasveer ; Li, Jiong ; Vestergaard, Mogens ; Obel, Carsten ; Kristensen, Jette Kolding ; Olsen, Jørn</creatorcontrib><description>The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the association between prenatal exposure to maternal bereavement during preconception and pregnancy and development of type-2 diabetes in the off-spring.
We utilized data from the Danish Civil Registration System to identify singleton births in Denmark born January 1(st) 1979 through December 31(st) 2008 (N = 1,878,246), and linked them to their parents, grandparents, and siblings. We categorized children as exposed to bereavement during prenatal life if their mothers lost an elder child, husband or parent during the period from one year before conception to the child's birth. We identified 45,302 children exposed to maternal bereavement; the remaining children were included in the unexposed cohort. The outcome of interest was diagnosis of type-2 diabetes. We estimated incidence rate ratios (IRRs) from birth using log-linear poisson regression models and used person-years as the offset variable. All models were adjusted for maternal residence, income, education, marital status, sibling order, calendar year, sex, and parents' history of diabetes at the time of pregnancy.
We found children exposed to bereavement during their prenatal life were more likely to have a type-2 diabetes diagnosis later in life (aIRR: 1.31, 1.01-1.69). These findings were most pronounced when bereavement was caused by death of an elder child (aIRR: 1.51, 0.94-2.44). Results also indicated the second trimester of pregnancy to be the most sensitive period of bereavement exposure (aIRR:2.08, 1.15-3.76).
Our data suggests that fetal exposure to maternal bereavement during preconception and the prenatal period may increase the risk for developing type-2 diabetes in childhood and young adulthood.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0043508</identifier><identifier>PMID: 22952698</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Age ; Analysis ; Animal models ; Animals ; Bereavement ; Birth ; Child ; Child, Preschool ; Children ; Children & youth ; Cohort Studies ; Complications and side effects ; Critical period ; Dehydrogenases ; Denmark ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - metabolism ; Diagnosis ; Education ; Endocrinology ; Etiology ; Exposure ; Female ; Fetuses ; Grief ; Handbooks ; Health risk assessment ; Health risks ; Hospitals ; Humans ; Hypertension ; Infant ; Infant, Newborn ; Insulin ; Insulin resistance ; Longitudinal Studies ; Male ; Marital status ; Maternal Exposure ; Medicine ; Mothers ; Offspring ; Parent educational background ; Parents ; Physiology ; Poisson density functions ; Population studies ; Population-based studies ; Pregnancy ; Pregnancy Trimester, Second ; Pregnant women ; Prenatal experience ; Prenatal exposure ; Prenatal Exposure Delayed Effects - epidemiology ; Prognosis ; Psychological aspects ; Public health ; Registration ; Regression analysis ; Regression models ; Risk factors ; Social and Behavioral Sciences ; Statistical analysis ; Stress ; Type 2 diabetes</subject><ispartof>PloS one, 2012-08, Vol.7 (8), p.e43508</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Li et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Li et al 2012 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-21dc69e96984b5ecf416b76d59c3b9dd72e5d2483758736e68152ee5309669d73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429491/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429491/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22952698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Virk, Jasveer</creatorcontrib><creatorcontrib>Li, Jiong</creatorcontrib><creatorcontrib>Vestergaard, Mogens</creatorcontrib><creatorcontrib>Obel, Carsten</creatorcontrib><creatorcontrib>Kristensen, Jette Kolding</creatorcontrib><creatorcontrib>Olsen, Jørn</creatorcontrib><title>Prenatal exposure to bereavement and type-2 diabetes: a Danish longitudinal population based study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the association between prenatal exposure to maternal bereavement during preconception and pregnancy and development of type-2 diabetes in the off-spring.
We utilized data from the Danish Civil Registration System to identify singleton births in Denmark born January 1(st) 1979 through December 31(st) 2008 (N = 1,878,246), and linked them to their parents, grandparents, and siblings. We categorized children as exposed to bereavement during prenatal life if their mothers lost an elder child, husband or parent during the period from one year before conception to the child's birth. We identified 45,302 children exposed to maternal bereavement; the remaining children were included in the unexposed cohort. The outcome of interest was diagnosis of type-2 diabetes. We estimated incidence rate ratios (IRRs) from birth using log-linear poisson regression models and used person-years as the offset variable. All models were adjusted for maternal residence, income, education, marital status, sibling order, calendar year, sex, and parents' history of diabetes at the time of pregnancy.
We found children exposed to bereavement during their prenatal life were more likely to have a type-2 diabetes diagnosis later in life (aIRR: 1.31, 1.01-1.69). These findings were most pronounced when bereavement was caused by death of an elder child (aIRR: 1.51, 0.94-2.44). Results also indicated the second trimester of pregnancy to be the most sensitive period of bereavement exposure (aIRR:2.08, 1.15-3.76).
Our data suggests that fetal exposure to maternal bereavement during preconception and the prenatal period may increase the risk for developing type-2 diabetes in childhood and young adulthood.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Analysis</subject><subject>Animal models</subject><subject>Animals</subject><subject>Bereavement</subject><subject>Birth</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Complications and side effects</subject><subject>Critical period</subject><subject>Dehydrogenases</subject><subject>Denmark</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diagnosis</subject><subject>Education</subject><subject>Endocrinology</subject><subject>Etiology</subject><subject>Exposure</subject><subject>Female</subject><subject>Fetuses</subject><subject>Grief</subject><subject>Handbooks</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Marital status</subject><subject>Maternal Exposure</subject><subject>Medicine</subject><subject>Mothers</subject><subject>Offspring</subject><subject>Parent educational background</subject><subject>Parents</subject><subject>Physiology</subject><subject>Poisson density functions</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnant women</subject><subject>Prenatal experience</subject><subject>Prenatal exposure</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Prognosis</subject><subject>Psychological aspects</subject><subject>Public health</subject><subject>Registration</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk factors</subject><subject>Social and Behavioral Sciences</subject><subject>Statistical analysis</subject><subject>Stress</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1rFDEUhgdRbK3-A9GAIHixayZfk_RCKPVroVDx6zZkJmd2s8xOxiRTuv_erDstu6AguUg4ec6bk5e3KJ6XeF7Sqny79mPoTTcffA9zjBnlWD4oTktFyUwQTB8enE-KJzGuMeZUCvG4OCFEcSKUPC3qLwF6k0yH4HbwcQyAkkc1BDA3sIE-IdNblLYDzAiyztSQIJ4jg96b3sUV6ny_dGm0Lo-CBj-MnUnO96g2ESyK-Wb7tHjUmi7Cs2k_K358_PD98vPs6vrT4vLiatYIRdKMlDYfQOWxWM2haVkp6kpYrhpaK2srAtwSJmnFZUUFCFlyAsApVkIoW9Gz4uVed-h81JM9UZeUCMYxZyQTiz1hvVnrIbiNCVvtjdN_Cj4stQnJNR1oAS1uZENbzIHJCmrBa8LbWrZY1rIxWevd9NpYb8A22apguiPR45verfTS32jKiGKqzAKvJoHgf40Q0z9GnqilyVO5vvVZrNm42OgLpiRhTPDd1-d_ofKysHFNDkjrcv2o4c1RQ2YS3KalGWPUi29f_5-9_nnMvj5gV2C6tIq-G3eZiMcg24NN8DEGaO-dK7He5fvODb3Lt57yndteHLp-33QXaPobNeT2CA</recordid><startdate>20120828</startdate><enddate>20120828</enddate><creator>Virk, Jasveer</creator><creator>Li, Jiong</creator><creator>Vestergaard, Mogens</creator><creator>Obel, Carsten</creator><creator>Kristensen, Jette Kolding</creator><creator>Olsen, Jørn</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20120828</creationdate><title>Prenatal exposure to bereavement and type-2 diabetes: a Danish longitudinal population based study</title><author>Virk, Jasveer ; Li, Jiong ; Vestergaard, Mogens ; Obel, Carsten ; Kristensen, Jette Kolding ; Olsen, Jørn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-21dc69e96984b5ecf416b76d59c3b9dd72e5d2483758736e68152ee5309669d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Analysis</topic><topic>Animal models</topic><topic>Animals</topic><topic>Bereavement</topic><topic>Birth</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Complications and side effects</topic><topic>Critical period</topic><topic>Dehydrogenases</topic><topic>Denmark</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diagnosis</topic><topic>Education</topic><topic>Endocrinology</topic><topic>Etiology</topic><topic>Exposure</topic><topic>Female</topic><topic>Fetuses</topic><topic>Grief</topic><topic>Handbooks</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Marital status</topic><topic>Maternal Exposure</topic><topic>Medicine</topic><topic>Mothers</topic><topic>Offspring</topic><topic>Parent educational background</topic><topic>Parents</topic><topic>Physiology</topic><topic>Poisson density functions</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnant women</topic><topic>Prenatal experience</topic><topic>Prenatal exposure</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Prognosis</topic><topic>Psychological aspects</topic><topic>Public health</topic><topic>Registration</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Risk factors</topic><topic>Social and Behavioral Sciences</topic><topic>Statistical analysis</topic><topic>Stress</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Virk, Jasveer</creatorcontrib><creatorcontrib>Li, Jiong</creatorcontrib><creatorcontrib>Vestergaard, Mogens</creatorcontrib><creatorcontrib>Obel, Carsten</creatorcontrib><creatorcontrib>Kristensen, Jette Kolding</creatorcontrib><creatorcontrib>Olsen, Jørn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Virk, Jasveer</au><au>Li, Jiong</au><au>Vestergaard, Mogens</au><au>Obel, Carsten</au><au>Kristensen, Jette Kolding</au><au>Olsen, Jørn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal exposure to bereavement and type-2 diabetes: a Danish longitudinal population based study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-08-28</date><risdate>2012</risdate><volume>7</volume><issue>8</issue><spage>e43508</spage><pages>e43508-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the association between prenatal exposure to maternal bereavement during preconception and pregnancy and development of type-2 diabetes in the off-spring.
We utilized data from the Danish Civil Registration System to identify singleton births in Denmark born January 1(st) 1979 through December 31(st) 2008 (N = 1,878,246), and linked them to their parents, grandparents, and siblings. We categorized children as exposed to bereavement during prenatal life if their mothers lost an elder child, husband or parent during the period from one year before conception to the child's birth. We identified 45,302 children exposed to maternal bereavement; the remaining children were included in the unexposed cohort. The outcome of interest was diagnosis of type-2 diabetes. We estimated incidence rate ratios (IRRs) from birth using log-linear poisson regression models and used person-years as the offset variable. All models were adjusted for maternal residence, income, education, marital status, sibling order, calendar year, sex, and parents' history of diabetes at the time of pregnancy.
We found children exposed to bereavement during their prenatal life were more likely to have a type-2 diabetes diagnosis later in life (aIRR: 1.31, 1.01-1.69). These findings were most pronounced when bereavement was caused by death of an elder child (aIRR: 1.51, 0.94-2.44). Results also indicated the second trimester of pregnancy to be the most sensitive period of bereavement exposure (aIRR:2.08, 1.15-3.76).
Our data suggests that fetal exposure to maternal bereavement during preconception and the prenatal period may increase the risk for developing type-2 diabetes in childhood and young adulthood.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22952698</pmid><doi>10.1371/journal.pone.0043508</doi><tpages>e43508</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-08, Vol.7 (8), p.e43508 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1326450542 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adult Age Analysis Animal models Animals Bereavement Birth Child Child, Preschool Children Children & youth Cohort Studies Complications and side effects Critical period Dehydrogenases Denmark Development and progression Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Diagnosis Education Endocrinology Etiology Exposure Female Fetuses Grief Handbooks Health risk assessment Health risks Hospitals Humans Hypertension Infant Infant, Newborn Insulin Insulin resistance Longitudinal Studies Male Marital status Maternal Exposure Medicine Mothers Offspring Parent educational background Parents Physiology Poisson density functions Population studies Population-based studies Pregnancy Pregnancy Trimester, Second Pregnant women Prenatal experience Prenatal exposure Prenatal Exposure Delayed Effects - epidemiology Prognosis Psychological aspects Public health Registration Regression analysis Regression models Risk factors Social and Behavioral Sciences Statistical analysis Stress Type 2 diabetes |
| title | Prenatal exposure to bereavement and type-2 diabetes: a Danish longitudinal population based study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T02%3A05%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prenatal%20exposure%20to%20bereavement%20and%20type-2%20diabetes:%20a%20Danish%20longitudinal%20population%20based%20study&rft.jtitle=PloS%20one&rft.au=Virk,%20Jasveer&rft.date=2012-08-28&rft.volume=7&rft.issue=8&rft.spage=e43508&rft.pages=e43508-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0043508&rft_dat=%3Cgale_plos_%3EA498244657%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1326450542&rft_id=info:pmid/22952698&rft_galeid=A498244657&rft_doaj_id=oai_doaj_org_article_6ef0c8c3f05e487eb65b25fb8f08b8ca&rfr_iscdi=true |