Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study

We found that Icaritin, an intestinal metabolite of Epimedium-derived flavonoids (EF) enhanced osteoblastic differentiation of mesenchymal stem cells (MSCs) only under osteogenic induction conditions. We also demonstrated its effect on inhibition of adipogenic differentiation of MSCs. Unlike the fin...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e41264-e41264
Hauptverfasser:	Yao, Dong, Xie, Xin-Hui, Wang, Xin-Luan, Wan, Chao, Lee, Yuk-Wai, Chen, Shi-Hui, Pei, Duan-Qing, Wang, Yi-Xiang, Li, Gang, Qin, Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antineoplastic Agents, Phytogenic - pharmacology Biocompatibility Biology Biomedical materials Bone and Bones - metabolism Bone growth Bone healing Bone marrow Bone Marrow Cells - cytology Cell Differentiation Cell growth Cell Movement Cell Proliferation Differentiation Drug dosages Drug Screening Assays, Antitumor Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Epimedium Fibroblasts Flavonoids Flavonoids - metabolism Flavonoids - pharmacology Gene expression Humans In Vitro Techniques Intestine Laboratories Medicine Mesenchymal stem cells Mesenchyme Metabolism Neovascularization, Pathologic Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteogenesis Osteogenesis - physiology Osteoporosis Phenotype R&D Research & development Rodents Stem cells Stem Cells - cytology Tetrazolium Salts - pharmacology Thiazoles - pharmacology Tissue engineering Umbilical vein Vascular endothelial growth factor
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