Bile acid binding resin improves metabolic control through the induction of energy expenditure

Besides well-established roles of bile acids (BA) in dietary lipid absorption and cholesterol homeostasis, it has recently become clear that BA is also a biological signaling molecule. We have shown that strategies aimed at activating TGR5 by increasing the BA pool size with BA administration may co...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e38286-e38286
Hauptverfasser:	Watanabe, Mitsuhiro, Morimoto, Kohkichi, Houten, Sander M, Kaneko-Iwasaki, Nao, Sugizaki, Taichi, Horai, Yasushi, Mataki, Chikage, Sato, Hiroyuki, Murahashi, Karin, Arita, Eri, Schoonjans, Kristina, Suzuki, Tatsuya, Itoh, Hiroshi, Auwerx, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Acids Activation Adipose tissue Adipose tissue (brown) Animal models Animals Bile Bile acids Bile Acids and Salts - chemistry Binding Biology Biosynthesis Cardiovascular disease Care and treatment Cholesterol Cholesterol - blood Cholesterol - metabolism Cholestyramine Resin - chemistry Composition effects Diabetes Diet Energy expenditure Energy Metabolism Enzymes Epichlorohydrin - chemistry Feedback Food intake Glucose Glucose - metabolism Glucose tolerance Glucose Tolerance Test Homeostasis Imidazoles - chemistry Insulin Insulin Resistance Internal medicine Laboratory animals Liver Male Medicine Metabolic syndrome Metabolic Syndrome - metabolism Metabolic syndrome X Mice Mice, Inbred C57BL Mice, Transgenic Models, Biological Obesity Physiological aspects Protein Binding Receptors, G-Protein-Coupled - metabolism Resins, Synthetic - chemistry Rodents Signal Transduction Signaling Thermogenesis Weight control Weight reduction
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