Cannabinoid receptor type 2 functional variant influences liver damage in children with non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of disease ranging from simple steatosis to inflammatory steatohepatitis (NASH) with different degrees of fibrosis that can ultimately progress to cirrhosis. Accumulating evidence suggests the involvement of the endocannabinoid-system in...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e42259-e42259
Hauptverfasser:	Rossi, Francesca, Bellini, Giulia, Alisi, Anna, Alterio, Arianna, Maione, Sabatino, Perrone, Laura, Locatelli, Franco, Miraglia del Giudice, Emanuele, Nobili, Valerio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animal models Biology Cannabinoid CB2 receptors Cannabinoids Care and treatment Child Childhood obesity Children Children & youth Cirrhosis Complications Cytokines Damage Dosage and administration Endocannabinoid system Enzymes Fatty liver Fatty Liver - genetics Fatty Liver - pathology Female Fibrosis Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease - genetics Genetic Variation Genomics Genotypes Health aspects Hematology Hepatology Humans Inflammation Laboratories Liver Liver - metabolism Liver - pathology Liver cirrhosis Liver diseases Male Mathematical models Medicine Metabolism Non-alcoholic Fatty Liver Disease Obesity Pediatrics Polymorphism Receptor, Cannabinoid, CB2 - genetics Rodents Steatosis
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