Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function

During kidney development, canonical Wnt signaling activates differentiation, while the transcription factor Six2 maintains the progenitor pool. These opposing signals help to regulate nephron formation and ensure the full complement of nephrons are formed. Since these two factors control differing...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e43098-e43098
Hauptverfasser:	Kiefer, Susan M, Robbins, Lynn, Rauchman, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tissues Animals Biochemistry Biological activity Biology Cell differentiation Cell Differentiation - genetics Cell Differentiation - physiology Cell fate Cre recombinase Creatinine Decisions Differentiation (biology) Gastrointestinal system Gastrointestinal tract Gene expression Gene Expression Regulation, Developmental - genetics Gene Expression Regulation, Developmental - physiology Genes Genetic engineering Genetic transformation Green Fluorescent Proteins - metabolism Homeodomain Proteins - metabolism In Situ Hybridization Internal medicine Kidney - cytology Kidney - embryology Kidneys Medicine Mesenchyme Mice Mice, Transgenic Molecular biology Nephrology Nephrons Proteins Pyloric sphincter Pylorus - abnormalities Recombinase Renal failure Rodents Signal Transduction - physiology Signaling SIX gene family Sphincter Stomach Stomach - embryology Transcription Factors - metabolism Transformation Transgenes - genetics Transgenic animals Transgenic mice Tubules Veterans Wnt protein Wnt Proteins - metabolism β-Catenin
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