Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis

Inflammation in the vascular wall is important for development of atherosclerosis. We have shown previously that arachidonate 15-lipoxygenase type B (ALOX15B) is more highly expressed in human atherosclerotic lesions than in healthy arteries. This enzyme oxidizes fatty acids to substances that promo...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e43142-e43142
Hauptverfasser:	Magnusson, Lisa U, Lundqvist, Annika, Karlsson, Merja Nurkkala, Skålén, Kristina, Levin, Max, Wiklund, Olov, Borén, Jan, Hultén, Lillemor Mattsson
Format:	Artikel
Sprache:	eng
Schlagworte:	8s-lipoxygenase Accumulation Angiogenesis Animals Arachidonate 15-lipoxygenase Arachidonate 15-Lipoxygenase - metabolism Arteries Arteriosclerosis Atherosclerosis Atherosclerosis - complications Atherosclerosis - enzymology Atherosclerosis - pathology Biology Bone marrow Bone marrow transplantation Cell and Molecular Biology Cell- och molekylärbiologi Chemokines Cytokines Cytokines - metabolism deficient mice double-edged-sword Endothelium Enzymes expression Fatty acids Foam Foam Cells - cytology Foam Cells - metabolism Foams Gene expression Gene Knockdown Techniques Gene Silencing Humans identification Inflammation Inflammation - complications Inflammation - metabolism interleukin-2 Laboratories ldl Lesions Lipids Lipoprotein (low density) receptors Lipoproteins (low density) Lipoxygenase Low density lipoprotein Low density lipoproteins Macrophages Macrophages - metabolism Medicine Mice Mice, Knockout oxidative modification Receptors, LDL - deficiency RNA, Small Interfering Rodents Transplantation
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