Probing the binding sites of antibiotic drugs doxorubicin and N-(trifluoroacetyl) doxorubicin with human and bovine serum albumins

We located the binding sites of doxorubicin (DOX) and N-(trifluoroacetyl) doxorubicin (FDOX) with bovine serum albumin (BSA) and human serum albumins (HSA) at physiological conditions, using constant protein concentration and various drug contents. FTIR, CD and fluorescence spectroscopic methods as...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e43814
Hauptverfasser:	Agudelo, Daniel, Bourassa, Philippe, Bruneau, Julie, Bérubé, Gervais, Asselin, Eric, Tajmir-Riahi, Heidar-Ali
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Albumins Amino acids Animals Anthracyclines Antibiotics Binding Sites Biology Bovine serum albumin Cattle Chemical bonds Chemical properties Chemistry Complexation Destabilization Docking Doxorubicin Doxorubicin - pharmacokinetics Drugs Fluorescence Fourier transforms Humans Hydrophobicity Investigations Medicine Models, Molecular Molecular modelling Physiological aspects Physiology Polyamines Properties Protein Binding Protein Conformation Protein structure Proteins Serum albumin Serum Albumin - metabolism Spectrum analysis Stability analysis Structural analysis Structural stability Trifluoroacetyl
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