Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif

Innate immune responses against DNA are essential to counter both pathogen infections and tissue damages. Mammalian EYAs were recently shown to play a role in regulating the innate immune responses against DNA. Here, we demonstrate that the unique Drosophila eya gene is also involved in the response...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e42725-e42725
Hauptverfasser:	Liu, Xi, Sano, Teruyuki, Guan, Yongsheng, Nagata, Shigekazu, Hoffmann, Jules A, Fukuyama, Hidehiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antiinfectives and antibacterials Biological evolution Biology Blotting, Western Conserved Sequence Deoxyribonuclease Deoxyribonucleic acid DNA Drosophila Drosophila - genetics Drosophila melanogaster Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - physiology Ears & hearing Endodeoxyribonucleases - metabolism Eya gene Eye Proteins - chemistry Eye Proteins - genetics Eye Proteins - physiology Gene expression Genetic aspects Gram-negative bacteria Haploinsufficiency Health aspects Immune response Immune system Immunology Immunoprecipitation Inflammation Innate immunity Insects Kinases Life Sciences Mammals Medicine Molecular Sequence Data Mutants Mutation Peptides Phosphatase Phosphatases Phosphoprotein Phosphatases - chemistry Phosphoprotein Phosphatases - metabolism Protein-tyrosine-phosphatase Proteins Science Sequence Homology, Amino Acid Threonine Threonine phosphatase Transcription factors Transcription Factors - metabolism Tumor necrosis factor-TNF Tyrosine
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