Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice

Viral and bacterial respiratory tract infections in early-life are linked to the development of allergic airway inflammation and asthma. However, the mechanisms involved are not well understood. We have previously shown that neonatal and infant, but not adult, chlamydial lung infections in mice perm...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e42588-e42588
Hauptverfasser:	Starkey, Malcolm R, Kim, Richard Y, Beckett, Emma L, Schilter, Heidi C, Shim, Doris, Essilfie, Ama-Tawiah, Nguyen, Duc H, Beagley, Kenneth W, Mattes, Joerg, Mackay, Charles R, Horvat, Jay C, Hansbro, Philip M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Alveoli Animals Animals, Newborn Asthma Asthma - etiology Asthma - immunology Asthma - pathology Babies Biology Bone marrow Bone Marrow Transplantation Chlamydia Chlamydia Infections - complications Chlamydia Infections - immunology Chlamydia Infections - pathology Chlamydia muridarum Cytokines Dendritic cells Dendritic structure Female Haemophilus influenzae Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - pathology Immune system Immunology Infants Infection Infections Inflammation Interleukin 13 Interleukin 5 Interleukin-13 - immunology Interleukin-5 - immunology Interleukins Lung diseases Lymphocytes T Male Medical research Medicine Mice Mice, Inbred BALB C Mucus Neonates Newborn babies Newborn infants Ovalbumin Pharmacy Phenotypes Physiological aspects Pneumonia, Bacterial - complications Pneumonia, Bacterial - immunology Pneumonia, Bacterial - pathology Pulmonary Alveoli - immunology Pulmonary Alveoli - microbiology Pulmonary Alveoli - pathology Respiratory diseases Respiratory tract Respiratory tract diseases Sexually transmitted diseases STD Stem cells Streptococcus infections Streptococcus pneumoniae T cells Transplantation Chimera - immunology Transplantation, Homologous Vaccines
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