Molecular marker identification for relapse prediction in 5-FU-based adjuvant chemotherapy in gastric and colorectal cancers

To confirm the clinical significance of NF-κB and JNK protein expression from experimentally identified candidates for predicting prognosis for patients with 5-FU treatment, we evaluated the protein expression of surgically removed specimens. A total of 79 specimens were obtained from 30 gastric and...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e43236
Hauptverfasser:	Ishida, Kazushige, Nishizuka, Satoshi S, Chiba, Takehiro, Ikeda, Miyuki, Kume, Kohei, Endo, Fumitaka, Katagiri, Hirokatsu, Matsuo, Teppei, Noda, Hironobu, Iwaya, Takeshi, Yamada, Noriyuki, Fujiwara, Hisataka, Takahashi, Masanori, Itabashi, Tetsuya, Uesugi, Noriyuki, Maesawa, Chihaya, Tamura, Gen, Sugai, Tamotsu, Otsuka, Koki, Koeda, Keisuke, Wakabayashi, Go
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant chemotherapy Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - pharmacology Apoptosis Biology Biomarkers Biomarkers, Tumor - metabolism Biotechnology Cancer Cancer therapies Care and treatment Cell cycle Cell Line, Tumor Chemotherapy Chemotherapy, Adjuvant - methods Cluster Analysis Colon Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism DNA microarrays Fluorouracil - pharmacology Gastric cancer Gastrointestinal system Gastrointestinal tract Gene Expression Regulation, Neoplastic Humans Immunohistochemistry - methods JNK protein Laboratories MAP Kinase Kinase 4 - metabolism Medical prognosis Medical research Medicine Middle Aged NF-κB protein Pathology Patients Predictions Prognosis Protein expression Proteins Recurrence RNA, Small Interfering - metabolism Science siRNA Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Subgroups Surgery Survival Tumor cell lines
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