Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats

Berberine, a major pharmacological component of the Chinese herb Coptis chinensis, which was originally used to treat bacterial diarrhea, has recently been demonstrated to be clinically effective in alleviating type 2 diabetes. In this study, we revealed that berberine effectively prevented the deve...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e42529
Hauptverfasser:	Zhang, Xu, Zhao, Yufeng, Zhang, Menghui, Pang, Xiaoyan, Xu, Jia, Kang, Chaoying, Li, Meng, Zhang, Chenhong, Zhang, Zhiguo, Zhang, Yifei, Li, Xiaoying, Ning, Guang, Zhao, Liping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adipose tissue Adiposity - drug effects Animals Berberine Berberine - pharmacology Berberine - therapeutic use Bioavailability Biology Biotechnology Body fat Body weight Chemistry Cholesterol Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diarrhea Diet Diet, High-Fat Digestive system Digestive tract Fatty acids Fatty Acids, Volatile - metabolism Feces - chemistry Feeding Behavior - drug effects Firmicutes Food intake Gastrointestinal tract Gastrointestinal Tract - drug effects Gastrointestinal Tract - microbiology Gene expression High fat diet Inflammation - complications Inflammation - pathology Insulin Insulin Resistance Intestinal microflora Intestine Kinases Laboratories Lactobacillus Least-Squares Analysis Leptin Life sciences Lipopolysaccharide-binding protein Lipoproteins Male Mathematical models Medicine Metabolic disorders Metagenome - drug effects Metagenome - genetics Microbiota Microbiota (Symbiotic organisms) Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Obesity Obesity - complications Obesity - drug therapy Obesity - microbiology Obesity - prevention & control Pharmacology Phenotype Phylogeny Prevention Protein binding Proteins Rats Rats, Wistar Redundancy Regression analysis Regression models Rodents rRNA 16S Type 2 diabetes Weight control Weight Gain - drug effects
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