Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry

Cells that exhibit an absolute dependence on the anti-apoptotic BCL-2 protein for survival are termed "primed for death" and are killed by the BCL-2 antagonist ABT-737. Many cancers exhibit a primed phenotype, including some that are resistant to conventional chemotherapy due to high BCL-2...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e42487-e42487
Hauptverfasser:	Clerc, Pascaline, Carey, Gregory B, Mehrabian, Zara, Wei, Michael, Hwang, Hyehyun, Girnun, Geoffrey D, Chen, Hegang, Martin, Stuart S, Polster, Brian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesiology Aniline Compounds - pharmacology Animals Apoptosis B-cell lymphoma Bax protein bcl-2 Homologous Antagonist-Killer Protein - metabolism Bcl-2 protein bcl-2-Associated X Protein - metabolism Biochemistry Bioenergetics Biology Biomarkers Biphenyl Compounds - pharmacology Cancer therapies Cancer treatment Caspase Cell Death - drug effects Cell Line Cell Line, Tumor Cell Respiration - drug effects Chemotherapy Clinical trials Cytochrome Cytochrome c Cytochromes c - metabolism Cytological Techniques - instrumentation Cytological Techniques - methods Death Electron transport Electron transport chain Embryo fibroblasts Embryos Energy Metabolism - drug effects Enzyme-linked immunosorbent assay Epithelial cells Fibroblasts Humans Impairment Leukemia Lymphocytes B Lymphoma Lymphoma, B-Cell - pathology Lymphomas Mammary gland Mcl-1 protein Medical research Medicine Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism Models, Biological Molecular biology Mortality Multiple myeloma Multiplexing Nitrophenols - pharmacology Oxygen Consumption - drug effects Phenotype Phenotypes Piperazines - pharmacology Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Reduction Respiration Respirometry Sulfonamides - pharmacology Tumor cell lines Tumors
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