Modulation of MicroRNA-194 and cell migration by HER2-targeting trastuzumab in breast cancer

Trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of the HER2 oncoprotein, can effectively target HER2-positive breast cancer through several mechanisms. Although the effects of trastuzumab on cancer cell proliferation, angiogenesis and apoptosis have been invest...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e41170-e41170
Hauptverfasser:	Le, Xiao-Feng, Almeida, Maria I, Mao, Weiqun, Spizzo, Riccardo, Rossi, Simona, Nicoloso, Milena S, Zhang, Shu, Wu, Yun, Calin, George A, Bast, Jr, Robert C
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Angiogenesis Animals Antibodies, Monoclonal, Humanized - pharmacology Antibodies, Monoclonal, Humanized - therapeutic use Apoptosis Biology Biopsy Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Cancer metastasis Cell adhesion & migration Cell culture Cell cycle Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Movement - genetics Cell proliferation Cell Proliferation - drug effects Chemotherapy Cytoskeleton ErbB-2 protein Female Flow Cytometry Gene expression Health sciences Humans Immunoblotting Immunotherapy Inhibition Kinases Liver cancer Luciferase Medicine Metastasis Mice Mice, Nude MicroRNA MicroRNAs MicroRNAs - drug effects MicroRNAs - genetics MicroRNAs - metabolism miRNA Monoclonal antibodies Penicillin Receptor, ErbB-2 - antagonists & inhibitors Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA Stem cells Talin - genetics Talin - metabolism Targeted cancer therapy Trastuzumab Xenografts
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