Enhanced antitumor efficacy of a vascular disrupting agent combined with an antiangiogenic in a rat liver tumor model evaluated by multiparametric MRI

A key problem in solid tumor therapy is tumor regrowth from a residual viable rim after treatment with a vascular disrupting agent (VDA). As a potential solution, we studied a combined treatment of a VDA and antiangiogenic. This study was approved by the institutional ethical committee for the use a...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e41140
Hauptverfasser:	Chen, Feng, Feng, Yingmei, Zheng, Kaier, De Keyzer, Frederik, Li, Junjie, Feng, Yuanbo, Cona, Marlein Miranda, Wang, Huaijun, Jiang, Yansheng, Yu, Jie, Marchal, Guy, Verfaillie, Catherine, De Geest, Bart, Oyen, Raymond, Ni, Yicheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - administration & dosage Animals Antiangiogenics Anticancer properties Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antitumor activity Apoptosis Biology Brain cancer Cancer therapies Cells (biology) Chemical compounds Chemokine CXCL12 - blood Combined treatment Delay Diffusion coefficient Disruption Effectiveness Endothelial Cells - cytology Ethical standards Ethics Histochemistry Histopathology Humans Laboratory animals Laboratory tests Liver Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - drug therapy Magnetic resonance imaging Magnetic Resonance Imaging - methods Medicine Microcirculation Necrosis NMR Nuclear magnetic resonance Organophosphorus Compounds - administration & dosage Permeability Pharmacology Rats Regression analysis Regrowth Solid tumors Stem cells Stem Cells - cytology Surgical implants Synergistic effect Thalidomide Thalidomide - administration & dosage Tumors
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