High avidity cytotoxic T lymphocytes can be selected into the memory pool but they are exquisitely sensitive to functional impairment

High avidity cytotoxic T lymphocytes (CTL) are important in viral clearance and anti-tumor immunity, however, mechanisms for their optimal generation and maintenance in vivo remain unclear. Immunizing mice with an antibody-DNA vaccine encoding a single CTL epitope, induces a 100 fold higher avidity...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e41112-e41112
Hauptverfasser:	Brentville, Victoria A, Metheringham, Rachael L, Gunn, Barbara, Durrant, Lindy G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Animals Antibodies Anticancer properties Antigenic determinants Antigens Antitumor agents Apoptosis Avidity Biology CD223 antigen Cell activation Cell death Cell Line Cell Line, Tumor Cell Proliferation Cloning Control systems Cytokines Cytotoxicity Deoxyribonucleic acid DNA DNA vaccines Enzyme-Linked Immunosorbent Assay Epitopes Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Exhaustion Female Flow Cytometry Humans Immune clearance Immune system Immunity Immunization Infections Ligands Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Medicine Melanoma Memory cells Metastasis Mice Mice, Inbred C57BL Oncology PD-1 protein Penicillin Peptides Signaling Stimulation T cell receptors T cells T-cell receptor T-Lymphocytes, Cytotoxic - immunology Tumor cells Tumors Vaccination Vaccines Vaccines, DNA - immunology Viral infections
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