Association between tetrodotoxin resistant channels and lipid rafts regulates sensory neuron excitability

Voltage-gated sodium channels (VGSCs) play a key role in the initiation and propagation of action potentials in neurons. Na(V)1.8 is a tetrodotoxin (TTX) resistant VGSC expressed in nociceptors, peripheral small-diameter neurons able to detect noxious stimuli. Na(V)1.8 underlies the vast majority of...

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Veröffentlicht in:	PloS one 2012-08, Vol.7 (8), p.e40079
Hauptverfasser:	Pristerà, Alessandro, Baker, Mark D, Okuse, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Axons beta-Cyclodextrins - pharmacology Biology Calcium Calcium imaging Channels Cholesterol Chronic pain Cyclodextrin Cyclodextrins Dissociation Drug Resistance - drug effects Enzyme Inhibitors - pharmacology Excitability Female Ganglia, Spinal - metabolism Immunoglobulins Inflammation Ketocholesterols - pharmacology Kinases Lipid rafts Lipids Localization Marine toxins Membrane lipids Membrane Microdomains - metabolism Methyl-β-Cyclodextrin Molecular biology NAV1.8 Voltage-Gated Sodium Channel - metabolism Neurons Nociceptors Nociceptors - metabolism Pain Pain perception Potassium Protein Transport - drug effects Proteins Rafts Rats Rats, Wistar Rodents Sciatic nerve Signal transduction Sodium Sodium Channel Blockers - pharmacology Sodium channels (voltage-gated) Spatial distribution Sphingolipids Tetrodotoxin Tetrodotoxin - pharmacology Trauma
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