BLM and RMI1 alleviate RPA inhibition of TopoIIIα decatenase activity

RPA is a single-stranded DNA binding protein that physically associates with the BLM complex. RPA stimulates BLM helicase activity as well as the double Holliday junction dissolution activity of the BLM-topoisomerase IIIα complex. We investigated the effect of RPA on the ssDNA decatenase activity of...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e41208-e41208
Hauptverfasser:	Yang, Jay, Bachrati, Csanad Z, Hickson, Ian D, Brown, Grant W
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biochemistry Biology Carrier Proteins - metabolism Complex formation Cooperation Deoxyribonucleic acid Dissolution DNA DNA helicase DNA Topoisomerases, Type I - metabolism DNA-Binding Proteins - metabolism Enzyme Activation Escherichia coli Proteins - metabolism Genomes Inhibition Metabolism Multiprotein Complexes - metabolism Physics Protein Binding Proteins RecQ Helicases - metabolism Replication Protein A - antagonists & inhibitors Replication Protein A - metabolism Single-stranded DNA
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