Functional epistatic interaction between rs6046G>A in F7 and rs5355C>T in SELE modifies systolic blood pressure levels

Although numerous genetic studies have been performed, only 0.9% of blood pressure phenotypic variance has been elucidated. This phenomenon could be partially due to epistatic interactions. Our aim was to identify epistatic interaction(s) associated with blood pressure levels in a pre-planned two-ph...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40777-e40777
Hauptverfasser:	El Shamieh, Said, Ndiaye, Ndeye Coumba, Stathopoulou, Maria G, Murray, Helena A, Masson, Christine, Lamont, John V, Fitzgerald, Peter, Benetos, Athanase, Visvikis-Siest, Sophie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alleles Biology Blood Blood pressure Blood Pressure - genetics Cell adhesion & migration E-Selectin - genetics Epistasis Epistasis, Genetic Factor VII - genetics Female Gene expression Gene Expression Regulation Genetic Predisposition to Disease Genetics Genomics Humans Intercellular adhesion molecule 1 Leukocytes (mononuclear) Male Medicine Middle Aged Peripheral blood mononuclear cells Phenotypic variations Polymorphism, Single Nucleotide - genetics Preventive medicine Rodents Studies Systole - genetics
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