Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors

The protein tyrosine phosphatase receptor J, PTPRJ, is a tumor suppressor gene that has been implicated in a range of cancers, including breast cancer, yet little is known about its role in normal breast physiology or in mammary gland tumorigenesis. In this paper we show that PTPRJ mRNA is expressed...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40742-e40742
Hauptverfasser:	Smart, Chanel E, Askarian Amiri, Marjan E, Wronski, Ania, Dinger, Marcel E, Crawford, Joanna, Ovchinnikov, Dmitry A, Vargas, Ana Cristina, Reid, Lynne, Simpson, Peter T, Song, Sarah, Wiesner, Christiane, French, Juliet D, Dave, Richa K, da Silva, Leonard, Purdon, Amy, Andrew, Megan, Mattick, John S, Lakhani, Sunil R, Brown, Melissa A, Kellie, Stuart
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Analysis Animals Biology Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Breast Neoplasms - pathology Brown, Stuart Carcinoma Cell Differentiation - genetics Cell Line, Tumor Deoxyribonucleic acid Differentiation DNA Down-Regulation - genetics Ectopic expression Epithelial cells Epithelial Cells - enzymology Epithelial Cells - pathology Epithelium - enzymology Epithelium - pathology Female Gene Dosage - genetics Gene Expression Regulation, Neoplastic Genes Genetic Loci - genetics Genetic research Genomes Humans Immunohistochemistry Introns - genetics Invasiveness Kinases Localization Lung cancer Mammary gland Mammary Glands, Animal - enzymology Mammary Glands, Animal - growth & development Mammary Glands, Animal - pathology Mammary Glands, Human - enzymology Mammary Glands, Human - pathology Mammary Neoplasms, Animal - enzymology Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - pathology Medical research Medicine Meta-Analysis as Topic Mice Mice, Inbred C57BL Phenols (Class of compounds) Phosphatase Phosphatases Pregnancy Protein-tyrosine-phosphatase Proteins Qualitative analysis Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism RNA RNA, Antisense - genetics RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Transcription Tumor suppressor genes Tumorigenesis Tumors Tyrosine
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