Mitochondrial genome variations in advanced stage endometriosis: a study in South Indian population

Endometriosis is a chronic gynecological benign disease that shares several features similar to malignancy. Mitochondrial DNA (mtDNA) mutations have been reported in all most all types of tumors. However, it is not known as to whether mtDNA mutations are associated with endometriosis. We sequenced t...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40668
Hauptverfasser:	Govatati, Suresh, Tipirisetti, Nageswara Rao, Perugu, Shyam, Kodati, Vijaya Lakshmi, Deenadayal, Mamata, Satti, Vishnupriya, Bhanoori, Manjula, Shivaji, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Amino Acid Sequence Analysis Base Sequence Biochemistry Biology Biomarkers Case-Control Studies Codons Computational Biology Deoxyribonucleic acid Development and progression Disease DNA DNA Mutational Analysis DNA, Mitochondrial - genetics Electron Transport Complex I - chemistry Electron Transport Complex I - genetics Endometriosis Endometriosis - genetics Endometriosis - pathology Endometrium Female Gene Deletion Gene mutation Genes Genetic aspects Genetic Predisposition to Disease Genetic Variation Genetics Genome, Mitochondrial - genetics Genomes Genomics Germ-Line Mutation - genetics Glycine Haplotypes - genetics Health risks Heteroplasmy Homology Humans India Infertility Leukocytes Malignancy Medicine Metabolism Microsatellite Instability Missense mutation Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Mitochondrial Proteins - chemistry Mitochondrial Proteins - genetics Molecular Sequence Data Mutagenesis Mutation Mutation, Missense ND5 gene Neoplasm Staging Ovarian cancer Oxidative stress Pathogenesis Patients Population studies Serine Stability Thyroid gland Tissue analysis Tissues Tumors Variation Womens health
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