Association of a BMP9 haplotype with ossification of the posterior longitudinal ligament (OPLL) in a Chinese population

Direct or ex vivo BMP9 adenoviral gene therapy can induce massive bone formation at the injection sites and clearly promote spinal fusion. A comprehensive analysis of the osteogenic activity indicated that BMP9 was one of the most potent inducers of osteogenic differentiation both in vitro and in vi...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40587-e40587
Hauptverfasser:	Ren, Yuan, Liu, Zhi-zhong, Feng, Jie, Wan, Hong, Li, Jun-hua, Wang, Hao, Lin, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Asian Continental Ancestry Group - genetics Biocompatibility Biology Biomedical materials Bone growth Bone marrow Bone morphogenetic protein 9 Demographics Deoxyribonucleic acid DNA Female Gene therapy Genetic aspects Genetic diversity Genetic Predisposition to Disease - genetics Growth Differentiation Factors - genetics Haplotypes Haplotypes - genetics Hospitals Humans In vivo methods and tests Inducers Ligaments Linkage analysis Linkage Disequilibrium Male Medical imaging Medicine Middle Aged Musculoskeletal system Mutation Neurosurgery NMR Nuclear magnetic resonance Ossification Ossification of Posterior Longitudinal Ligament - genetics Osteogenesis Patients Polymerase chain reaction Polymorphism, Single Nucleotide - genetics Population Population (statistical) Population studies Proteins Regression analysis Risk factors Rodents Single nucleotide polymorphisms Single-nucleotide polymorphism Spine Statistical analysis Stem cells Studies Vertebrae Young Adult
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