Autism-relevant social abnormalities and cognitive deficits in engrailed-2 knockout mice

ENGRAILED 2 (En2), a homeobox transcription factor, functions as a patterning gene in the early development and connectivity of rodent hindbrain and cerebellum, and regulates neurogenesis and development of monoaminergic pathways. To further understand the neurobiological functions of En2, we conduc...

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Veröffentlicht in:	PloS one 2012-07, Vol.7 (7), p.e40914-e40914
Hauptverfasser:	Brielmaier, Jennifer, Matteson, Paul G, Silverman, Jill L, Senerth, Julia M, Kelly, Samantha, Genestine, Matthieu, Millonig, James H, DiCicco-Bloom, Emanuel, Crawley, Jacqueline N
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adults Alternation learning Anatomy Animal cognition Animals Anxiety Autism Autistic Disorder - genetics Autistic Disorder - physiopathology Behavior Biology Biotechnology Brain Brain - physiology Brain architecture Brain stem Brain Stem - physiology Cerebellum Chemical communication Child psychology Cognition Disorders - genetics Cognition Disorders - physiopathology Cognitive ability Cortex (olfactory) Cortex (somatosensory) Dentistry Disorders Engrailed-2 protein Exploratory behavior Fear conditioning Gene expression Genetic aspects Genotypes Grip strength Haplotypes Hippocampus - physiology Homeobox Homeodomain Proteins Hypothalamus Hypothalamus - physiology Laboratory animals Locomotor activity Maze learning Maze Learning - physiology Medical schools Medicine Mental depression Mental disorders Mental health Mice Mice, Knockout Mutants Mutation Neostriatum Nerve Tissue Proteins Neural networks Neurogenesis Neurosciences Pain Pattern formation Phenotyping Psychopharmacology Rodents Signal Transduction Signaling Social aspects Social Behavior Social factors Social interactions Somatosensory cortex Somatosensory Cortex - physiology Thalamus Transcription (Genetics) Vocalization behavior
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